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L-Myc expression by dendritic cells is required for optimal T-cell priming

被引：0
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作者：
Wumesh KC
Ansuman T. Satpathy
Aaron S. Rapaport
Carlos G. Briseño
Xiaodi Wu
Jörn C. Albring
Emilie V. Russler-Germain
Nicole M. Kretzer
Vivek Durai
Stephen P. Persaud
Brian T. Edelson
Jakob Loschko
Marina Cella
Paul M. Allen
Michel C. Nussenzweig
Marco Colonna
Barry P. Sleckman
Theresa L. Murphy
Kenneth M. Murphy
机构：
[1] Washington University School of Medicine,Department of Pathology and Immunology
[2] 660 S. Euclid Avenue,Department of Medicine A
[3] St Louis,undefined
[4] Missouri 63110,undefined
[5] USA,undefined
[6] Hematology and Oncology,undefined
[7] University of Muenster,undefined
[8] 48149 Muenster,undefined
[9] Germany,undefined
[10] Laboratory of Molecular Immunology,undefined
[11] Howard Hughes Medical Institute,undefined
[12] The Rockefeller University,undefined
[13] Howard Hughes Medical Institute,undefined
[14] Washington University School of Medicine,undefined
[15] 660 S. Euclid Avenue,undefined
[16] St Louis,undefined
[17] Missouri 63110,undefined
[18] USA,undefined
来源：
Nature | 2014年 / 507卷
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摘要：
L-Myc, a paralogue of the proto-oncogene c-Myc, is shown to regulate dendritic cell homeostasis and functionality; unlike c-Myc, L-Myc is not repressed by interferons and its expression allows for optimal dendritic cell proliferation and T-cell priming in the presence of inflammation.
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页码：243 / 247
页数：4
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