Peptidomimetics Through Click Chemistry: Synthesis of Novel β-Keto Triazole Acids from N-Protected Amino Acids

被引：0

作者：

N. Narendra

T. M. Vishwanatha

Vommina V. Sureshbabu

机构：

[1] Bangalore University,Peptide Research Laboratory, Department of Studies in Chemistry

来源：

International Journal of Peptide Research and Therapeutics | 2010年 / 16卷

关键词：

-Urethane protected azidomethylketones; Cu(I) catalyzed cycloaddition reaction; -Urethane protected β-keto triazole acids; β-Keto triazole linked dipeptidomemitics;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

An efficient procedure for the preparation of azidomethylketones from N-urethane protected amino acids and their application in Cu(I) catalyzed azide-alkyne cycloaddition reaction are described. The synthesis has been carried out under mild conditions with all the commonly used urethane protected (Fmoc, Boc and Z) amino acids and the desired azides/triazoles were obtained in good yields. Incorporation of these triazole amino acids into small peptides generating dipeptidomimetics containing β-keto triazole units has also been demonstrated.

引用

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页码：283 / 290

页数：7

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