Hypoglycemic, lipid lowering and antioxidant activities in root extract of Anthocephalus indicus in alloxan induced diabetic rats

被引：4
|
作者：
Kumar V. [1 ]
Khanna A.K. [4 ]
Khan M.M. [4 ]
Singh R. [1 ]
Singh S. [1 ]
Chander R. [1 ]
Mahdi F. [2 ]
Saxena J.K. [4 ]
Saxena S. [3 ]
Singh V.K. [1 ]
Singh R.K. [1 ,5 ]
机构：
[1] Era's Lucknow Medical College, Lucknow
[2] BRD Medical College, Gorakhpur
[3] Division of Biochemistry, Central Drug Research Institute, Lucknow
[4] Department of Biochemistry, Chhatrapati Shahuji Maharaj Medical University (King George's Medical University)
来源：
Indian Journal of Clinical Biochemistry | 2009年 / 24卷 / 1期
关键词：
Anthocephalus indicus; Hypoglycemic agent; Lipid lowering agent; Oxygen free radical scavengers; Plant antioxidant;
D O I：
10.1007/s12291-009-0011-4
中图分类号：
学科分类号：
摘要：
The present study was carried out to evaluate the hypoglycemic, lipid lowering and antioxidant activities in root extract of Anthocephalus indicus (A indicus) in alloxan inducd diabetic rats. Oral administration of ethanol extract of root (500mg/ kg body weight) for 21 days resulted in significant decrease in the levels of blood glucose, triglycerides, total cholesterol, phospholipid and free fatty acids. Furthermore, the root extract (100-400μg) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro. The result of the present study demonstrated hypoglycemic, lipid lowering and antioxidant activities in root extract of A indicus, which could help in prevention of diabetic dyslipidemia and related diseases. © 2009 Association of Clinical Biochemists of India.
引用
收藏
页码：65 / 69
页数：4
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