Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites

被引：0

作者：

Tao Long

Michael Hicks

Hung-Chun Yu

William H Biggs

Ewen F Kirkness

Cristina Menni

Jonas Zierer

Kerrin S Small

Massimo Mangino

Helen Messier

Suzanne Brewerton

Yaron Turpaz

Brad A Perkins

Anne M Evans

Luke A D Miller

Lining Guo

C Thomas Caskey

Nicholas J Schork

Chad Garner

Tim D Spector

J Craig Venter

Amalio Telenti

机构：

[1] Human Longevity,Department of Twin Research and Genetic Epidemiology

[2] Inc.,undefined

[3] San Diego,undefined

[4] California,undefined

[5] USA,undefined

[6] King's College,undefined

[7] Health Nucleus,undefined

[8] Human Longevity Singapore,undefined

[9] Pte. Ltd.,undefined

[10] Metabolon,undefined

[11] Inc.,undefined

[12] Molecular and Human Genetics,undefined

[13] Baylor College of Medicine,undefined

[14] J. Craig Venter Institute,undefined

[15] Present address: Sanford Burnham Prebys Medical Discovery Institute,undefined

[16] La Jolla,undefined

[17] California,undefined

[18] USA.,undefined

来源：

Nature Genetics | 2017年 / 49卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Amalio Telenti, Craig Venter and colleagues report common, low-frequency and rare variants associated with blood metabolite levels using whole-genome sequencing and comprehensive metabolite profiling in 1,960 individuals. They identify 246 metabolites whose levels are associated with genetic variation at 101 loci.

引用

页码：568 / 578

页数：10

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