The synchronized catalytic dance of CRISPR-Cas9

被引：0
|
作者：
Aakash Saha
Chinmai Pindi
Giulia Palermo
机构：
[1] The University of California,Department of Bioengineering
[2] The University of California,Department of Chemistry
来源：
Nature Catalysis | 2023年 / 6卷
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摘要：
CRISPR-Cas9 is a major gene-editing tool that has attracted tremendous interdisciplinary efforts to ameliorate precise genome manipulation. Now, the pivotal structural features behind concerted double-stranded DNA cleavages by the Cas9 endonuclease have been captured through cryo-electron microscopy, laying the groundwork for improved Cas9 engineering.
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页码：870 / 872
页数：2
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