Synthesis and cytotoxic activity of N-[(alkylsulfanyl)methyl]- and N-[(arylsulfanyl)methyl]benzamides

被引：0
|
作者：
R. R. Khairullina
U. Sh. Kuzmina
L. R. Yakupova
Yu. V. Vakhitova
机构：
[1] Ufa Federal Research Center of the Russian Academy of Sciences,Institute of Petrochemistry and Catalysis
[2] Ufa Federal Research Center of the Russian Academy of Sciences,Institute of Biochemistry and Genetics
来源：
Russian Chemical Bulletin | 2023年 / 72卷
关键词：
thiomethylation; aminobenzamides; thiols; paraformaldehyde; -[(alkylsulfanyl)methyl]benzamides; -[(arylsulfanyl)methyl]benzamides; cytotoxic activity; catalysis;
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中图分类号：
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摘要：
A catalytic approach for the synthesis of N-[(alkylsulfanyl)methyl]- and N-[(arylsulfanyl)methyl]benzamides was developed via thiomethylation of 2-, 3- and 4-aminobenzamides with alkylthio- or arylthiomethanols. A moderate cytotoxic activity of 4-s[(heptylthio)methyl]aminobenzamide was established against a number of cell lines, with the most pronounced effect against the Jurkat leukemic T-cell line.
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页码：2501 / 2507
页数：6
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