Synthesis and alkylation of 1-substituted 3-thioxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitriles

被引：0

作者：

I. V. Dyachenko

M. V. Vovk

机构：

[1] Taras Shevchenko Lugansk National University,Institute of Organic Chemistry

[2] National Academy of Sciences of Ukraine,undefined

来源：

Russian Journal of Organic Chemistry | 2012年 / 48卷

关键词：

Yellow Powder; Anhydrous Ethanol; BuOH; Sodium Ethoxide; Cyanothioacetamide;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The condensation of cyclohexylidene(cyano)thioacetamides with aldehydes or of 2-acyl-1-(morpholin-4-yl)cycloalkenes with dithiomalonamide gave 1-alkyl(aryl)-3-thioxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitriles. Reactions of the latter with various alkylating agents selectively produced the corresponding isoquinolin-3-yl sulfides or products of their subsequent Thorpe cyclization, thieno[2,3-c]isoquinolines.

引用

页码：1544 / 1549

页数：5

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