Reductive dehalogenation of chlorinated dioxins by an anaerobic bacterium

被引:0
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作者
Michael Bunge
Lorenz Adrian
Angelika Kraus
Matthias Opel
Wilhelm G. Lorenz
Jan R. Andreesen
Helmut Görisch
Ute Lechner
机构
[1] Institut für Mikrobiologie,
[2] Martin-Luther-Universität Halle-Wittenberg,undefined
[3] Institut für Analytik und Umweltchemie,undefined
[4] Martin-Luther-Universität Halle-Wittenberg,undefined
[5] Fachgebiet Technische Biochemie,undefined
[6] Institut für Biotechnologie der Technischen Universität Berlin,undefined
[7] GfA Gesellschaft für Arbeitsplatz- und Umweltanalytik mbH,undefined
来源
Nature | 2003年 / 421卷
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摘要
Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs and PCDFs) are among the most notorious environmental pollutants. Some congeners, particularly those with lateral chlorine substitutions at positions 2, 3, 7 and 8, are extremely toxic and carcinogenic to humans1. One particularly promising mechanism for the detoxification of PCDDs and PCDFs is microbial reductive dechlorination. So far only a limited number of phylogenetically diverse anaerobic bacteria have been found that couple the reductive dehalogenation of chlorinated compounds—the substitution of a chlorine for a hydrogen atom—to energy conservation and growth in a process called dehalorespiration2. Microbial dechlorination of PCDDs occurs in sediments and anaerobic mixed cultures from sediments, but the responsible organisms have not yet been identified or isolated. Here we show the presence of a Dehalococcoides species in four dioxin-dechlorinating enrichment cultures from a freshwater sediment highly contaminated with PCDDs and PCDFs. We also show that the previously described chlorobenzene-dehalorespiring bacterium Dehalococcoides sp. strain CBDB1 (ref. 3) is able to reductively dechlorinate selected dioxin congeners. Reductive dechlorination of 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PeCDD) demonstrates that environmentally significant dioxins are attacked by this bacterium.
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页码:357 / 360
页数:3
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