Mesenchymal stem cells and their microenvironment

被引：0
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作者：
Jiaxi Liu
Jinfang Gao
Zixie Liang
Chong Gao
Qing Niu
Fengping Wu
Liyun Zhang
机构：
[1] Third Hospital of Shanxi Medical University,Department of Biomedical Engineering
[2] Shanxi Bethune Hospital,Department of Pathology, Harvard Medical School
[3] Shanxi Academy of Medical Sciences,undefined
[4] Tongji Shanxi Hospital,undefined
[5] Duke University Pratt School of Engineering,undefined
[6] Brigham and Women’s Hospital,undefined
来源：
Stem Cell Research & Therapy | / 13卷
关键词：
Mesenchymal stem cells; Microenvironment; Immunomodulation; Tissue regeneration;
D O I：
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中图分类号：
学科分类号：
摘要：
Mesenchymal stem cells (MSCs), coming from a wide range of sources, have multi-directional differentiation ability. MSCs play vital roles in immunomodulation, hematopoiesis and tissue repair. The microenvironment of cells often refers to the intercellular matrix, other cells, cytokines and humoral components. It is also the place for cells’ interaction. The stability of the microenvironment is pivotal for maintaining cell proliferation, differentiation, metabolism and functional activities. Abnormal changes in microenvironment components can interfere cell functions. In some diseases, MSCs can interact with the microenvironment and accelerate disease progression. This review will discuss the characteristics of MSCs and their microenvironment, as well as the interaction between MSCs and microenvironment in disease.
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