The secretases: enzymes with therapeutic potential in Alzheimer disease

被引：0

作者：

Bart De Strooper

Robert Vassar

Todd Golde

机构：

[1] Center for Human Genetics,Department of Cell and Molecular Biology

[2] VIB and KULeuven,Department of Neuroscience

[3] Northwestern University,undefined

[4] Mayo Clinic College of Medicine,undefined

[5] Mayo Clinic Florida,undefined

来源：

Nature Reviews Neurology | 2010年 / 6卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The three secretases that process amyloid precursor protein are central to the generation of amyloid-β, and the accumulation of this peptide in extracellular plaques is one of the hallmarks of Alzheimer disease. In this Review, De Strooper et al. discuss the evidence that suggests that these enzymes are potential therapeutic targets for Alzheimer disease drug treatments.

引用

页码：99 / 107

页数：8

共 50 条

[1] The secretases: enzymes with therapeutic potential in Alzheimer disease
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[J]. NATURE REVIEWS NEUROLOGY, 2010, 6 (02) : 99 - 107
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