Secretases as therapeutic targets in Alzheimer's disease: patents 2000-2004

被引：15
|
作者：
Larner, A [1 ]
机构：
[1] Walton Ctr Neurol & Neurosurg, Cognit Funct Clin, Liverpool L9 7LJ, Merseyside, England
来源：
EXPERT OPINION ON THERAPEUTIC PATENTS | 2004年 / 14卷 / 10期
关键词：
alpha-secretase; beta-secretase; gamma-secretase; Alzheimer's disease; amyloid peptide; inhibitor;
D O I：
10.1517/13543776.14.10.1403
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
This article briefly reviews the biology of the secretase enzymes <alpha, beta and gamma> that metabolise the amyloid precursor protein, pathways that are believed to be central to the pathogenesis of Alzheimer's disease. Therapeutic patents claiming secretase inhibitors or modulators for the treatment of Alzheimer's disease published over the last 4 years are then considered. Although there are many claims, no agent has yet reached the clinical arena, and the paucity of data provided in the patents makes it difficult to predict which, if any, might do so.
引用
收藏
页码：1403 / 1420
页数：18
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