"Essentiality" testing: Looking for new antimicrobial targets

被引：1
|
作者：
David Knowles
Gary Patou
机构：
[1] Ladywell House,
[2] Ribotargets,undefined
[3] SmithKline Beecham Pharmaceuticals,undefined
来源：
Current Infectious Disease Reports | 1999年 / 1卷 / 5期
关键词：
Peptide Nucleic Acid; Bacterial Gene Expression; Antimicrobial Target; Bacterial Virulence Gene; Control Expression System;
D O I：
10.1007/s11908-999-0063-x
中图分类号：
学科分类号：
摘要：
After a gap of some 30 years, the prospect of finding completely new agents with which to combat infectious disease is promising. New discovery approaches based on the application of genomics and associated technologies are leading to the identification of genes essential for bacterial viability and pathogenesis. This article reviews the current status of the search for new antimicrobial targets and points to future developments and issues.
引用
收藏
页码：488 / 494
页数：6
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