The design of new molecular "light switches" for DNA

被引：0
|
作者：
Xiao-Hua Zou
Bao-Hui Ye
Hong Li
Qian-Ling Zhang
Hui Chao
Jin-Gang Liu
Liang-Nian Ji
Xiao-Yuan Li
机构：
[1] State Key Laboratory of Ultrafast Laser Spectroscopy/Department of Chemistry,
[2] Zhongshan University,undefined
[3] Guangzhou 510275,undefined
[4] P.R. China,undefined
[5] Department of Chemistry,undefined
[6] Hong Kong University of Science and Technology,undefined
[7] Clear Water Bay,undefined
[8] Hong Kong,undefined
来源：
JBIC Journal of Biological Inorganic Chemistry | 2001年 / 6卷
关键词：
Syntheses Ruthenium complex DNA Molecular light switch;
D O I：
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学科分类号：
摘要：
Two novel ruthenium(II) complexes, [Ru(pztp)2(phen)](ClO4)2 and [Ru(pztp)2(bpy)](ClO4)2, have been synthesized and characterized by UV/Vis and 1H NMR spectroscopies and mass spectrometry. The MeCN solutions of both complexes display fluorescence that was found to be highly sensitive to the presence and concentration of water. The complexes behave like a "light switch" for DNA in that they do not luminesce in water but were "turned on" in the presence of DNA and show emission enhancement with the increase of DNA concentration. Their DNA binding behavior was also studied by absorption spectroscopy and viscosity measurements, which suggest that the DNA-complex interaction involves intercalation of the metal-bound pztp ligand into the base pairs of duplex DNA.
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页码：143 / 150
页数：7
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