Synthesis of 7-oxopyrrolo-[3,2-d]pyrimidine 5-oxides by the rearrangement of 6-alkynyl-5-nitropyrimidines

被引：0
|
作者：
Tumkevicius S. [1 ]
Susvilo I. [1 ]
Brukstus A. [1 ]
机构：
[1] Organic Chemistry Department, Vilnius University
来源：
Chemistry of Heterocyclic Compounds | 2004年 / 40卷 / 10期
关键词：
Alkynes; Catalysis; Nitropyrimidines; Palladium; Pyrrolo[3,2-d]pyrimidines; Rearrangement;
D O I：
10.1007/s10593-005-0074-y
中图分类号：
学科分类号：
摘要：
A method is proposed for the synthesis of 6-substituted 4-amino-7-oxopyrrolo[2,3-d]pyrimidine 5-oxides which includes a Sonogashira reaction of 4-amino-6-chloro-5-nitropyrimidine with terminal alkynes and subsequent rearrangement of the 6-alkynyl-5-nitropyrimidines obtained. © 2004 Springer Science+Business Media, Inc.
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页码：1335 / 1338
页数：3
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