Prdm4 induction by the small molecule butein promotes white adipose tissue browning

被引：0
|
作者：
Song N.-J. [1 ]
Choi S. [2 ]
Rajbhandari P. [10 ]
Chang S.-H. [1 ]
Kim S. [1 ]
Vergnes L. [4 ]
Kwon S.-M. [1 ]
Yoon J.-H. [1 ]
Lee S. [5 ]
Ku J.-M. [6 ]
Lee J.-S. [7 ,8 ]
Reue K. [4 ,9 ]
Koo S.-H. [2 ]
Tontonoz P. [3 ,10 ]
Park K.W. [1 ]
机构：
[1] Department of Food Science and Biotechnology, Sungkyunkwan University, Suwon
[2] Division of Life Sciences, Korea University, Seoul
[3] Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA
[4] Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA
[5] Department of Genetic Engineering, Sungkyunkwan University, Suwon
[6] Natural Product Research Team, Gyeonggi Bio-Center, Gyeonggi Institute of Science and Technology Promotion, Suwon
[7] Korea Research Institute of Bioscience and Biotechnology, Daejeon
[8] Major of Functional Genomics, University of Science and Technology, Daejeon
[9] Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA
[10] Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA
来源：
Nature Chemical Biology | 2016年 / 12卷 / 7期
基金：
美国国家卫生研究院; 新加坡国家研究基金会;
关键词：
D O I：
10.1038/nchembio.2081
中图分类号：
学科分类号：
摘要：
Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue. © 2016 Nature America, Inc. All rights reserved.
引用
收藏
页码：479 / 481
页数：2
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