PrP genotype in Sarda breed sheep and its relevance to scrapie

被引：0
|
作者：
G. Vaccari
R. Petraroli
U. Agrimi
C. Eleni
M. G. Perfetti
M. A. Di Bari
L. Morelli
C. Ligios
L. Busani
R. Nonno
G. Di Guardo
机构：
[1]  Istituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana,
[2] Rome,undefined
[3] Italy,undefined
[4]  Applied Biosystems,undefined
[5] Via Ciamarra,undefined
[6] Rome,undefined
[7] Italy,undefined
[8]  Laboratory of Veterinary Medicine,undefined
[9] Istituto Superiore di Sanità,undefined
[10] Rome,undefined
[11] Italy,undefined
[12]  Istituto Zooprofilattico Sperimentale della Sardegna,undefined
[13] Sassari,undefined
[14] Italy,undefined
来源：
Archives of Virology | 2001年 / 146卷
关键词：
Codon; Gene Polymorphism; Brain Homogenate; Scrapie; Breed Sheep;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
 Several PrP gene polymorphisms modulate sheep scrapie susceptibility. Recently, an increase of scrapie outbreaks has been reported in Italy. A vaccine containing sheep brain homogenate was used in most of the outbreaks. We investigated PrP gene polymorphisms in scrapie-affected and clinically healthy Sarda breed sheep from a flock exposed to the aforementioned vaccine, and in affected Sarda sheep from unexposed flocks. All affected animals were (Gln/Gln)171 homozygous. Moreover, we observed no variation for Ala136 and a new polymorphism (Lys to Asn) at codon 176. Our findings confirm the correlation between scrapie and (Gln/Gln)171 in breeds with no variation for Ala136.
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页码：2029 / 2037
页数：8
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