PrP genotype in Sarda breed sheep and its relevance to scrapie

被引：0

作者：

G. Vaccari

R. Petraroli

U. Agrimi

C. Eleni

M. G. Perfetti

M. A. Di Bari

L. Morelli

C. Ligios

L. Busani

R. Nonno

G. Di Guardo

机构：

[1] Istituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana,

[2] Rome,undefined

[3] Italy,undefined

[4] Applied Biosystems,undefined

[5] Via Ciamarra,undefined

[6] Rome,undefined

[7] Italy,undefined

[8] Laboratory of Veterinary Medicine,undefined

[9] Istituto Superiore di Sanità,undefined

[10] Rome,undefined

[11] Italy,undefined

[12] Istituto Zooprofilattico Sperimentale della Sardegna,undefined

[13] Sassari,undefined

[14] Italy,undefined

来源：

Archives of Virology | 2001年 / 146卷

关键词：

Codon; Gene Polymorphism; Brain Homogenate; Scrapie; Breed Sheep;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Several PrP gene polymorphisms modulate sheep scrapie susceptibility. Recently, an increase of scrapie outbreaks has been reported in Italy. A vaccine containing sheep brain homogenate was used in most of the outbreaks. We investigated PrP gene polymorphisms in scrapie-affected and clinically healthy Sarda breed sheep from a flock exposed to the aforementioned vaccine, and in affected Sarda sheep from unexposed flocks. All affected animals were (Gln/Gln)171 homozygous. Moreover, we observed no variation for Ala136 and a new polymorphism (Lys to Asn) at codon 176. Our findings confirm the correlation between scrapie and (Gln/Gln)171 in breeds with no variation for Ala136.

引用

页码：2029 / 2037

页数：8

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