Radiation therapy before radical cystectomy combined with immunotherapy in locally advanced bladder cancer – study protocol of a prospective, single arm, multicenter phase II trial (RACE IT)

被引：0

作者：

Sebastian C. Schmid

Florestan J. Koll

Claus Rödel

Philipp Maisch

Andreas Sauter

Franziska Beckert

Anna Seitz

Hubert Kübler

Michael Flentje

Felix Chun

Stephanie E. Combs

Kilian Schiller

Jürgen E. Gschwend

Margitta Retz

机构：

[1] Technical University of Munich,Department of Urology, School of Medicine, Rechts der Isar Medical Center

[2] University of Frankfurt,Department of Radiation Oncology

[3] Technical University of Munich,Department of Diagnostic and Interventional Radiology, School of Medicine, Rechts der Isar Medical Center

[4] University of Würzburg,Department of Urology

[5] University of Würzburg,Department of Radiation Oncology

[6] University of Frankfurt,Department of Urology

[7] Technical University of Munich,Department of Radiation Oncology, School of Medicine, Rechts der Isar Medical Center

[8] Helmholtz Zentrum München (HMGU),undefined

[9] Institute of Radiation Medicine (IRM),undefined

[10] Deutsches Konsortium für Translationale Krebsforschung (NeoDKTK) Partner Site Munich,undefined

来源：

BMC Cancer | / 20卷

关键词：

Bladder cancer; Urothelial cancer; Transitional cell carcinoma; Locally advanced; Immunotherapy; Radiotherapy; Radical cystectomy; Nivolumab; Checkpoint inhibitor; PD-1 inhibitor;

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[1] Radiation therapy before radical cystectomy combined with immunotherapy in locally advanced bladder cancer - study protocol of a prospective, single arm, multicenter phase II trial (RACE IT)
Schmid, Sebastian C.
Koll, Florestan J.
Roedel, Claus
Maisch, Philipp
Sauter, Andreas
Beckert, Franziska
Seitz, Anna
Kuebler, Hubert
Flentje, Michael
Chun, Felix
Combs, Stephanie E.
Schiller, Kilian
Gschwend, Juergen E.
Retz, Margitta
[J]. BMC CANCER, 2020, 20 (01)
[2] RACE IT - A prospective, single arm, multicenter, phase II-trial to assess safety and efficacy of preoperative RAdiation therapy before radical CystEctomy combined with ImmunoTherapy in locally advanced urothelial carcinoma of the bladder (AB 65/18)
Schmid, S. C.
Schiller, K.
Seitz, A. K.
Koll, F. J.
Beckert, F.
Korn, P.
Lewerich, J.
Maisch, P.
Sauter, A.
Roedel, C.
Flentje, M.
Riedel, T.
Combs, S.
Zengerling, F.
Bolenz, C.
Kuebler, H.
Gschwend, J. E.
Retz, M.
[J]. EUROPEAN UROLOGY, 2022, 81 : S510 - S510
[3] RACE IT: A prospective, single arm, multicenter, phase II-trial to assess safety and efficacy of preoperative radiation therapy before radical cystectomy combined with immunotherapy in locally advanced urothelial carcinoma of the bladder (AB 65/18)
Schmid, S. C.
Beckert, F.
Koll, F.
Roedel, C.
Seitz, A. K.
Maisch, P.
Sauter, A.
Kuebler, H.
Flentje, M.
Combs, S. E.
Schiller, K.
Gschwend, J.
Retz, M.
[J]. ANNALS OF ONCOLOGY, 2020, 31 : S605 - S605
[4] RACE IT: A prospective, single arm, multicenter, phase II-trial to assess safety and efficacy of preoperative RAdiation therapy before radical CystEctomy combined with ImmunoTherapy in locally advanced urothelial carcinoma of the bladder (AB 65/18) - first results
Schmid, S. C.
Schiller, K.
Lewerich, J.
Seitz, A. K.
Sauter, A.
Koll, F.
Beckert, F.
Korn, P.
Maisch, P.
Roedel, C.
Flentje, M.
Wiegel, T.
Combs, S.
Zengerling, F.
Bolenz, C.
Kuebler, H.
Gschwend, J.
Retz, M.
[J]. ANNALS OF ONCOLOGY, 2022, 33 (07) : S1442 - S1442
[5] Race IT-Preoperative Radiation Therapy Before Radical Cystectomy Combined with Immunotherapy in Locally Advanced Urothelial Carcinoma of the Bladder
Beckert, Franziska
Retz, Margitta
Lunger, Lukas
Maisch, Phillip
Roedel, Claus
Koll, Florestan
Sauter, Andreas
Seitz, Anna
Kuebler, Hubert
Flentje, Michael
Chun, Felix
Combs, Stephanie
Schiller, Kilian
Gschwend, Juergen
Schmid, Sebastian
[J]. ONCOLOGY RESEARCH AND TREATMENT, 2020, 43 : 225 - 226
[6] Combined Radiation-Immunotherapy in locally advanced Bladder Cancer Prospective, single-arm, multicenter Phase-II Study to evaluate Safety and Efficacy of preoperative Radioimmunotherapy followed by radical Cystectomy in locally advanced Bladder Cancer (RACE-IT) - AB 65/18 of AUO
Rexer, H.
Schmid, S.
Merseburger, A.
[J]. AKTUELLE UROLOGIE, 2020, 51 (02) : 101 - 102
[7] RACE IT - A prospective, multicenter, single-arm Phase II Study to Evaluate the Safety and Efficacy of preoperative Radiotherapy in Combination with immunomodulatory Therapy followed by radical Cystectomy in locally advanced Bladder Cancer
Schiller, K.
Roedel, C.
Vogel, M.
Beckert, F.
Flentje, M.
Koll, F. J.
Maisch, P.
Sauter, A.
Seitz, A.
Kuebler, H.
Chun, F.
Combs, S. E.
Gschwend, J. E.
Retz, M.
Schmid, S. C.
[J]. STRAHLENTHERAPIE UND ONKOLOGIE, 2020, 196 (SUPPL 1) : S154 - S154
[8] Prospective trial of adjuvant chemotherapy versus adjuvant radiation therapy for locally advanced bladder cancer after radical cystectomy
Zaghloul, Mohamed S.
Christodouleas, John Paul
Zaghloul, Tarek
Smith, Andrew
Abdalla, Ahmed
Khaled, Hussein Mustafa
William, Hany
Hwang, Wei-Ting
Baumann, Brian Christopher
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (06)
[9] Total neoadjuvant therapy for locally advanced gastric cancer and esophagogastric junction adenocarcinoma: study protocol for a prospective, multicenter, single-arm, phase II clinical trial
Shi, Jinming
Li, Ning
Tang, Yuan
Jiang, Liming
Yang, Lin
Wang, Shulian
Song, Yongwen
Liu, Yueping
Fang, Hui
Lu, Ningning
Qi, Shunan
Chen, Bo
Li, Ziyu
Liu, Shixin
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[J]. BMC GASTROENTEROLOGY, 2022, 22 (01)
[10] Total neoadjuvant therapy for locally advanced gastric cancer and esophagogastric junction adenocarcinoma: study protocol for a prospective, multicenter, single-arm, phase II clinical trial
Jinming Shi
Ning Li
Yuan Tang
Liming Jiang
Lin Yang
Shulian Wang
Yongwen Song
Yueping Liu
Hui Fang
Ningning Lu
Shunan Qi
Bo Chen
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Jun Wang
Wenling Wang
Suyu Zhu
Jialin Yang
Yexiong Li
Dongbing Zhao
Jing Jin
[J]. BMC Gastroenterology, 22

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