Assessing gene–treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program

被引：0
|
作者：
P. W. Franks
K. A. Jablonski
L. M. Delahanty
J. B. McAteer
S. E. Kahn
W. C. Knowler
J. C. Florez
机构：
[1] Umeå University Hospital,Genetic Epidemiology and Clinical Research Group, Department of Public Health and Clinical Medicine, Section for Medicine
[2] George Washington University,The Biostatistics Center
[3] Massachusetts General Hospital,Diabetes Unit
[4] Massachusetts General Hospital,Center for Human Genetic Research
[5] Broad Institute of Harvard and MIT,Program in Medical and Population Genetics
[6] VA Puget Sound Health Care System and University of Washington,Division of Metabolism, Endocrinology and Nutrition, Department of Medicine
[7] National Institutes of Health,Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases
[8] Harvard Medical School,Department of Medicine
[9] George Washington University,Diabetes Prevention Program Coordinating Center, The Biostatistics Center
来源：
Diabetologia | 2008年 / 51卷
关键词：
Adiposity; Diabetes Prevention Program; FTO; Gene–environment interaction; Genetic; INSIG2; Lifestyle; Metformin; Obesity; Randomised controlled trial; Troglitazone;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：2214 / 2223
页数：9
相关论文
共 40 条
  • [31] Physical Interactions and Expression Quantitative Traits Loci Identify Regulatory Connections for Obesity and Type 2 Diabetes Associated SNPs
    Fadason, Tayaza
    Ekblad, Cameron
    Ingram, John R.
    Schierding, William S.
    O'Sullivan, Justin M.
    FRONTIERS IN GENETICS, 2017, 8
  • [32] Association of Variants within the FTO and MC4R Genes with Obesity Related Traits and Type 2 Diabetes in Pakistani Populations
    Rees, Simon D.
    Hydrie, M. Z. I.
    Bellary, Srikanth
    O'Hare, J. P.
    Sanghera, Dharambir K.
    Kumar, Sudhesh
    Shera, A. S.
    Barnett, Anthony H.
    Basit, Abdul
    Kelly, M. A.
    DIABETES, 2010, 59 : A337 - A337
  • [33] Fine mapping reveals sex bias in quantitative trait loci affecting growth, skeletal size and obesity-related traits on mouse chromosomes 2 and 11
    Farber, Charles R.
    Medrano, Juan F.
    GENETICS, 2007, 175 (01) : 349 - 360
  • [34] Interactions among insulin resistance, inflammation factors, obesity-related gene polymorphisms, environmental risk factors, and diet in the development of gestational diabetes mellitus
    Feng, Yang
    Jiang, Chen-Dong
    Chang, Ai-Min
    Shi, Ying
    Gao, Junjun
    Zhu, Linlin
    Zhang, Zhan
    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2019, 32 (02): : 339 - 347
  • [35] The TCN2 Variant of rs9606756 [Ile23Val] Acts as Risk Loci for Obesity-Related Traits and Mediates by Interacting with Apo-A1
    Hebbar, Prashantha
    Alkayal, Fadi
    Nizam, Rasheeba
    Melhem, Motasem
    Elkum, Naser
    John, Sumi Elsa
    Abufarha, Mohamed
    Alsmadi, Osama
    Thanaraj, Thangavel Alphonse
    OBESITY, 2017, 25 (06) : 1098 - 1108
  • [36] Altered blood gene expression in the obesity-related type 2 diabetes cluster may be causally involved in lipid metabolism: a Mendelian randomisation study
    Juliette A. de Klerk
    Joline W. J. Beulens
    Hailiang Mei
    Roel Bijkerk
    Anton Jan van Zonneveld
    Robert W. Koivula
    Petra J. M. Elders
    Leen M. ’t Hart
    Roderick C. Slieker
    Diabetologia, 2023, 66 : 1057 - 1070
  • [37] Altered blood gene expression in the obesity-related type 2 diabetes cluster may be causally involved in lipid metabolism: a Mendelian randomisation study
    de Klerk, Juliette A.
    Beulens, Joline W. J.
    Mei, Hailiang
    Bijkerk, Roel
    van Zonneveld, Anton Jan
    Koivula, Robert W.
    Elders, Petra J. M.
    't Hart, Leen M.
    Slieker, Roderick C.
    DIABETOLOGIA, 2023, 66 (06) : 1057 - 1070
  • [38] Investigation of associations of European, African, Amerindian genomic ancestries and MC4R, FTO, FAIM2, BDNF loci with obesity- related traits in Rio de Janeiro, Brazil
    Scharf, Allan
    Bezerra, Flavia F.
    Zembrzuski, Veronica M.
    Da Fonseca, Ana Carolina P.
    Gusmao, Leonor
    Faerstein, Eduardo
    ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS, 2023, 95
  • [39] Polymorphic variants in the beta-3-adrenergic receptor gene and TNF-α genes do not influence traits related to Type 2 diabetes and obesity.
    Johnson, S
    Seibert, M
    Thorne, N
    Andersen, RE
    Walston, J
    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1999, 47 (09) : S21 - S21
  • [40] Four pairs of gene-gene interactions associated with increased risk for type 2 diabetes (CDKN2BAS-KCNJ11), obesity (SLC2A9-IGF2BP2, FTO-APOA5), and hypertension (MC4R-IGF2BP2) in Chinese women
    Wang, M. H.
    Li, J.
    Yeung, V. S. Y.
    Zee, B. C. Y.
    Yu, R. H. Y.
    Ho, S.
    Waye, M. M. Y.
    META GENE, 2014, 2 : 384 - 391
1234