A Novel Nanocapsule Delivery System to Overcome Intestinal Degradation and Drug Transport Limited Absorption of P-glycoprotein Substrate Drugs

被引:0
|
作者
Taher Nassar
Alona Rom
Abraham Nyska
Simon Benita
机构
[1] The Hebrew University of Jerusalem,Department of Pharmaceutics, School of Pharmacy
[2] Tel Aviv University,Consultant in Toxicological Pathology, Sackler School of Medicine
来源
Pharmaceutical Research | 2008年 / 25卷
关键词
CYP3A; nanocapsules; P-gp; tacrolimus;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:2019 / 2029
页数:10
相关论文
共 50 条
  • [41] A novel electron paramagnetic resonance approach to determine the mechanism of drug transport by P-glycoprotein
    Omote, H
    Al-Shawi, MK
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (47) : 45688 - 45694
  • [42] Modulation of intestinal P-glycoprotein function by polyethylene glycols and their derivatives by in vitro transport and in situ absorption studies
    Shen, Q
    Lin, YL
    Handa, T
    Doi, M
    Sugie, M
    Wakayama, K
    Okada, N
    Fujita, T
    Yamamoto, A
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2006, 313 (1-2) : 49 - 56
  • [43] Effects of intestinal CYP3A4 and P-glycoprotein on oral drug absorption - Theoretical approach
    Ito, K
    Kusuhara, H
    Sugiyama, Y
    PHARMACEUTICAL RESEARCH, 1999, 16 (02) : 225 - 231
  • [44] Effects of Intestinal CYP3A4 and P-Glycoprotein on Oral Drug Absorption—Theoretical Approach
    Kiyomi Ito
    Hiroyuki Kusuhara
    Yuichi Sugiyama
    Pharmaceutical Research, 1999, 16 : 225 - 231
  • [45] P-glycoprotein limits the absorption of the anti-HIV drug zidovudine through rat intestinal segments
    Quevedo, Mario A.
    Nieto, Leandro E.
    Brinon, Margarita C.
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2011, 43 (03) : 151 - 159
  • [46] DRUG ABSORPTION LIMITED BY P-GLYCOPROTEIN-MEDIATED SECRETORY DRUG TRANSPORT IN HUMAN INTESTINAL EPITHELIAL CACO-2 CELL-LAYERS
    HUNTER, J
    HIRST, BH
    SIMMONS, NL
    PHARMACEUTICAL RESEARCH, 1993, 10 (05) : 743 - 749
  • [47] Enhanced intestinal absorption of etoposide by self-microemulsifying drug delivery systems: Roles of P-glycoprotein and cytochrome P450 3A inhibition
    Zhao, Gang
    Huang, Jiangeng
    Xue, Kewen
    Si, Luqin
    Li, Gao
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2013, 50 (3-4) : 429 - 439
  • [48] Enhancement of paclitaxel transport and intestinal absorption using lipid polymer emulsions (LPE™) incorporating P-glycoprotein inhibitors
    Fast, DJ
    Patil, RT
    Bosman, KS
    Pokorsky-Loy, L
    Constantinides, PP
    JOURNAL OF CONTROLLED RELEASE, 2003, 91 (1-2) : 242 - 244
  • [49] Methodology for Development of a Physiological Model Incorporating CYP3A and P-Glycoprotein for the Prediction of Intestinal Drug Absorption
    Badhan, Raj
    Penny, Jeffrey
    Galetin, Aleksandra
    Houston, I. Brian
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 98 (06) : 2180 - 2197
  • [50] The Prediction of the Relative Importance of CYP3A/P-glycoprotein to the Nonlinear Intestinal Absorption of Drugs by Advanced Compartmental Absorption and Transit Model
    Takano, Junichi
    Maeda, Kazuya
    Bolger, Michael B.
    Sugiyama, Yuichi
    DRUG METABOLISM AND DISPOSITION, 2016, 44 (11) : 1808 - 1818