Near-infrared conjugated polymers for photoacoustic imaging-guided photothermal/chemo combination therapy

被引：18
|
作者：
Cao, Yue [1 ]
Wu, Yannan [2 ]
Wang, Guannan [2 ]
Yi, Jingwen [1 ]
Yu, Chunlei [2 ]
Huang, Yanxin [3 ]
Sun, Luguo [3 ]
Bao, Yongli [2 ]
Li, Yuxin [1 ]
机构：
[1] Northeast Normal Univ, Natl Engn Lab Druggable Gene & Prot Screening, Jingyue St 2555, Changchun 130117, Peoples R China
[2] Northeast Normal Univ, Sch Life Sci, Renmin St 5268, Changchun 130024, Peoples R China
[3] Northeast Normal Univ, Inst Genet & Cytol, Renmin St 5268, Changchun 130024, Peoples R China
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2017年 / 5卷 / 27期
基金：
中国国家自然科学基金;
关键词：
VIVO CANCER-THERAPY; IN-VIVO; GOLD NANOPARTICLES; ANTICANCER DRUGS; DELIVERY; AGENT; CELLS; NANOSPHERES; ABLATION; TUMORS;
D O I：
10.1039/c7tb01264k
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Conjugated polymers (CPs) with intensive near-infrared (NIR) absorption and high photothermal conversion efficiency (PCE) have emerged as a new generation of photothermal therapy (PTT) and photoacoustic imaging (PAI) agents for cancer therapy. PTT + chemotherapy has been identified as a powerful modality to offer synergistic effects in the destruction and monitoring of cancer tissues. In this study, diketopyrrolopyrrole-based polymers (DPP) were designed through a combination of donor-acceptor moieties. Then, doxorubicin (DOX) and DPP were co-encapsulated in tocopheryl polyethylene-glycolsuccinate-cholesterol (TPGS-CHO) copolymers to build a combined theranostic system for tumor treatment. These combined NPs with high PCE (similar to 50%) and strong (NIR) absorption exhibit excellent real-time photoacoustic imaging detection and synergistic cancer inhibition.
引用
收藏
页码：5479 / 5487
页数：9
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