Synthesis of indazol-4,7-dione derivatives as potential trypanocidal agents

被引：19

作者：

Tapia, RA

Carrasco, C

Ojeda, S

Salas, C

Valderrama, JA

Morello, A

Repetto, Y

机构：

[1] Pontificia Univ Catolica Chile, Fac Quim, Santiago, Chile

[2] Univ Chile, Fac Med, Dept Bioquim, Santiago 70086 7, Chile

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2002年 / 39卷 / 05期

关键词：

D O I：

10.1002/jhet.5570390540

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of new indazol-4,7-dione derivatives via 1,3-dipolar cycloaddition of diazomethane with 2,3-dimethyl-1,4-benzoquinone (2) and 1,4-naphthoquinone (7) followed by N-alkylation of the pyrazol nitrogen atom of the corresponding quinones (3) and (8) with methyl chloroacetate is described. A series of amides from esters (5) and (10) were also obtained. these compounds were tested in vitro as potential anti-trypanosomal agents. Compounds (4) and (8) were found to have significant activity.

引用

页码：1093 / 1096

页数：4

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