The tyrosine kinase activity of the chicken insulin receptor is similar to that of the human insulin receptor

被引：11

作者：

Kato, H ^{[1
]}

Okubo, Y

Matsumura, Y

Roberts, CT

Sugahara, K

LeRoith, D

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Chem, Bunkyo Ku, Tokyo 1138657, Japan

[2] NIDDKD, Clin Endocrine Branch, NIH, Bethesda, MD 20892 USA

[3] Utsunomiya Univ, Fac Agr, Dept Anim Sci, Utsunomiya, Tochigi 3218505, Japan

[4] Oregon Hlth Sci Univ, Dept Pediat, Portland, OR 97201 USA

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2000年 / 64卷 / 04期

关键词：

insulin receptor; chicken; tyrosine kinase; IRS-1;

D O I：

10.1271/bbb.64.903

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The tyrosine kinase activity of a chimeric insulin receptor composed of the extracellular domain of the human insulin receptor (IR) and the intracellular domain of the chicken IR was compared with wild-type human IR. The degrees of autophosphorylation, phosphorylation of IRS-1, and in vitro phosphorylation of an exogenous substrate after stimulation by human insulin were similar to that seen with the human IR. We conclude that the insulin resistance of chickens is not attributable to a lower level of intrinsic tyrosine kinase activity of IR.

引用

页码：903 / 906

页数：4

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