Optogenetic modulation in stroke recovery

被引：11

作者：

Pendharkar, Arjun V. ^{[1
]}

Levy, Sabrina L. ^{[1
]}

Ho, Allen L. ^{[1
]}

Sussman, Eric S. ^{[1
]}

Cheng, Michelle Y. ^{[1
]}

Steinberg, Gary K. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Neurosurg, Stanford, CA 94305 USA

来源：

NEUROSURGICAL FOCUS | 2016年 / 40卷 / 05期

关键词：

optogenetics; DREADD; designer receptor exclusively activated by designer drugs; stroke; ischemia; neuroregeneration; plasticity; PROMOTES FUNCTIONAL RECOVERY; OPTICAL CONTROL; NEURONAL HYPEREXCITABILITY; MILLISECOND-TIMESCALE; IONOTROPIC GLUTAMATE; BRAIN-STIMULATION; LIGHT ACTIVATION; GLIAL-CELLS; STEM-CELLS; THERAPY;

D O I：

10.3171/2016.2.FOCUS163

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Stroke is one of the leading contributors to morbidity, mortality, and health care costs in the United States. Although several preclinical strategies have shown promise in the laboratory, few have succeeded in the clinical setting. Optogenetics represents a promising molecular tool, which enables highly specific circuit-level neuromodulation. Here, the conceptual background and preclinical body of evidence for optogenetics are reviewed, and translational considerations in stroke recovery are discussed.

引用

页数：8

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