An Environmentally Sustainable Synthesis of Enantioenriched CF3-Chromanol, Indanol and Tetralol Derivatives by Rh-Catalyzed Asymmetric Transfer Hydrogenation

被引：7

作者：

Betancourt, Ricardo Molina ^{[1
]}

Bacheley, Lucas ^{[1
,2
]}

Karapetyan, Anzhela ^{[1
]}

Guillamot, Gerard ^{[2
]}

Phansavath, Phannarath ^{[1
]}

Ratovelomanana-Vidal, Virginie ^{[1
]}

机构：

[1] PSL Univ, Chim ParisTech, CNRS UMR 8060, 8060 Inst Chem Life & Hlth Sci,CSB2D Team, F-75005 Paris, France

[2] SEQENS, ZI Limay Porcheville, F-78440 Porcheville, France

来源：

CHEMCATCHEM | 2022年 / 14卷 / 15期

关键词：

asymmetric transfer hydrogenation; catalysis; green chemistry; rhodium; trifluoromethyl; KETONES; ACCESS; RESOLUTION; FLUORINE; COMPLEX; SCOPE;

D O I：

10.1002/cctc.202200595

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The Rh(III)-catalyzed asymmetric reduction of alpha-trifluoromethyl ketones through transfer hydrogenation was developed under mild conditions to access a series of enantioenriched cis-trifluoromethyl alcohols via a dynamic kinetic resolution process. The reaction was efficiently performed in the green solvent 2-MeTHF with HCO2H/Et3N (1 : 1) as the hydrogen source. High yields, alongside excellent diastereo- and enantioselectivities were obtained for the synthesis of CF3-chromanol, CF3-indanol and CF3-tetralol derivatives.

引用

页数：5

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