Unexpected Interactions of an Alternating Poly(ether-ester) with Artificial and Biological Bilipidic Membranes

被引：4

作者：

Illy, Nicolas ^{[1
]}

Bacri, Laurent ^{[2
]}

Wojno, Justyna ^{[1
]}

Destouches, Damien ^{[3
]}

Brissault, Blandine ^{[1
]}

Courty, Jose ^{[3
]}

Auvray, Loic ^{[2
]}

Penelle, Jacques ^{[1
]}

Barbier, Valessa ^{[1
]}

机构：

[1] Univ Paris Est, CNRS, ICMPE, UMR 7182, F-94320 Thiais, France

[2] Univ Evry, CNRS, UMR 7182, Grp Mat Polymeres Interfaces,UMR 7182, F-91025 Evry, France

[3] Univ Paris Est, CNRS, UMR 7149, Lab Rech Croissance Cellulaire Reparat & Regenera, F-94000 Creteil, France

来源：

MACROMOLECULAR SYMPOSIA | 2010年 / 287卷

关键词：

bilipidic membrane; cytotoxicity; ion transport; poly(ether-ester); pore; SYNTHETIC ION CHANNELS; RING-OPENING POLYMERIZATION; LIPID-MEMBRANES; BLOCK-COPOLYMERS; DERIVATIVES; PORES; CYCLOPROPANE-1,1-DICARBOXYLATE; HYDROLYSIS; DISRUPTION; TRANSPORT;

D O I：

10.1002/masy.201050109

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The anionic polymerization of a Spiro monomer containing both an ester-activated cyclopropane moiety and a 1,4,7,10,13-pentaoxacyclohexadecane-14,16-dione crown ether bislactone unexpectedly yielded a linear alternating poly(ether-ester) via the ring-opening polymerization of the crown ether cycle. Ion conductivity measurements using black lipid membranes as model systems showed that oligomers of this structure are able to permeabilize bilipidic membranes, with single-ion channel behaviors being observed. Biological assays on fibroblast cells indicated a significant cytotoxicity, probably related to the above permeabilization mechanism.

引用

页码：60 / 68

页数：9

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