Sequence of the FRA3B common fragile region:: Implications for the mechanism of FHIT deletion

被引：116

作者：

Inoue, H ^{[1
]}

Ishii, H ^{[1
]}

Alder, H ^{[1
]}

Snyder, E ^{[1
]}

Druck, T ^{[1
]}

Huebner, K ^{[1
]}

Croce, CM ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Jefferson Med Coll, Kimmel Canc Inst, Philadelphia, PA 19107 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1997年 / 94卷 / 26期

关键词：

D O I：

10.1073/pnas.94.26.14584

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The hypothesis that chromosomal fragile sites may be "weak links" that result in hot spots for cancer-specific chromosome rearrangements was supported by the discovery that numerous cancer cell homozygous deletions and a familial translocation map within the FHIT gene, which encompasses the common fragile site, FRA3B. Sequence analysis of 276 kb of the FRA3B/FHIT locus and 22 associated cancer cell deletion endpoints shows that this locus is a frequent target of homologous recombination between long interspersed nuclear element sequences resulting in FHIT gene internal deletions, probably as a result of carcinogen-induced damage at FRA3B fragile sites.

引用

页码：14584 / 14589

页数：6

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