Sequence of the FRA3B common fragile region:: Implications for the mechanism of FHIT deletion

被引：116
|
作者：
Inoue, H [1 ]
Ishii, H [1 ]
Alder, H [1 ]
Snyder, E [1 ]
Druck, T [1 ]
Huebner, K [1 ]
Croce, CM [1 ]
机构：
[1] Thomas Jefferson Univ, Jefferson Med Coll, Kimmel Canc Inst, Philadelphia, PA 19107 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1997年 / 94卷 / 26期
关键词：
D O I：
10.1073/pnas.94.26.14584
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The hypothesis that chromosomal fragile sites may be "weak links" that result in hot spots for cancer-specific chromosome rearrangements was supported by the discovery that numerous cancer cell homozygous deletions and a familial translocation map within the FHIT gene, which encompasses the common fragile site, FRA3B. Sequence analysis of 276 kb of the FRA3B/FHIT locus and 22 associated cancer cell deletion endpoints shows that this locus is a frequent target of homologous recombination between long interspersed nuclear element sequences resulting in FHIT gene internal deletions, probably as a result of carcinogen-induced damage at FRA3B fragile sites.
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收藏
页码：14584 / 14589
页数：6
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