Obesity-Related Asthma: Immune Regulation and Potential Targeted Therapies

被引：17

作者：

Yuan, Yuze ^{[1
]}

Ran, Nan ^{[1
]}

Xiong, Lingxin ^{[1
,2
]}

Wang, Guoqiang ^{[1
]}

Guan, Xuewa ^{[1
]}

Wang, Ziyan ^{[1
]}

Guo, Yingqiao ^{[1
]}

Pang, Zhiqiang ^{[1
]}

Fang, Keyong ^{[1
]}

Lu, Junying ^{[1
,3
]}

Zhang, Chao ^{[1
]}

Zheng, Ruipeng ^{[1
,4
]}

Zheng, Jingtong ^{[1
]}

Ma, Jie ^{[2
]}

Wang, Fang ^{[1
]}

机构：

[1] Jilin Univ, Dept Pathogeny Biol, Coll Basic Med Sci, Changchun 130021, Jilin, Peoples R China

[2] Jilin Univ, Sch Pharmaceut Sci, Changchun 130021, Jilin, Peoples R China

[3] Jilin Univ, Hosp 1, Dept Intens Care Unit, Changchun 130021, Jilin, Peoples R China

[4] Jilin Univ, Hosp 1, Dept Intervent Therapy, Changchun 130021, Jilin, Peoples R China

来源：

JOURNAL OF IMMUNOLOGY RESEARCH | 2018年 / 2018卷

关键词：

HIGH-FAT DIET; INNATE LYMPHOID-CELLS; INDUCED AIRWAY INFLAMMATION; GLUCAGON-LIKE PEPTIDE-1; GUT MICROBIOTA; LIPID-METABOLISM; ADIPOSE-TISSUE; INTESTINAL MICROBIOTA; INSULIN-RESISTANCE; WEIGHT-LOSS;

D O I：

10.1155/2018/1943497

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Obesity, one of the most severe public health problems of the 21st century, is a common metabolic syndrome due to excess body fat. The incidence and severity of obesity-related asthma have undergone a dramatic increase. Because obesity-related asthma is poorly controlled using conventional therapies, alternative and complementary therapies are urgently needed. Lipid metabolism may be abnormal in obesity-related asthma, and immune modulation therapies need to be investigated. Herein, we describe the immune regulators of lipid metabolism in obesity as well as the interplay of obesity and asthma. These lay the foundations for targeted therapies in terms of direct and indirect immune regulators of lipid metabolism, which ultimately help provide effective control of obesity-related asthma with a feasible treatment strategy.

引用

页数：13

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