Involvement of Platelet-Derived Growth Factor-BB and Its Receptor-β in Hypoxia-Induced Depression of Excitatory Synaptic Transmission in the Nucleus Tractus Solitarius of Mice

被引：6
|
作者：
Ohi, Yoshiaki [1 ]
Ishii, Yoko [2 ]
Sasahara, Masakiyo [2 ]
Haji, Akira [1 ]
机构：
[1] Aichi Gakuin Univ, Sch Pharm, Neuropharmacol Lab, Chikusa Ku, Nagoya, Aichi 4648650, Japan
[2] Toyama Univ, Dept Pathol, Grad Sch Med & Pharmaceut Sci, Toyama 9300194, Japan
来源：
JOURNAL OF PHARMACOLOGICAL SCIENCES | 2010年 / 112卷 / 04期
关键词：
platelet-derived growth factor (PDGF)-BB / PDGF receptor (PDGFR)-beta signal; hypoxia; excitatory synaptic transmission; PROTECTIVE ROLE; BRAIN-STEM; NEURONS;
D O I：
10.1254/jphs.09345SC
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The role of platelet-derived growth factor (PDGF)-BB / PDGF receptor (PDGFR)-beta signal in inhibition of synaptic transmission by hypoxia is unclear. In the nucleus tractus solitarius neurons, hypoxia with N-2 or NaCN decreased the amplitude of excitatory postsynaptic currents (EPSCs) similarly in wild type (WT) and PDGFR-beta gene-knockout (KO) mice. Recovery of EP SCs after a high concentration of NaCN in KO mice was significantly faster than that in WT mice, while recovery after a low concentration of NaCN or N-2 was not different between both mice. These results suggest that the PDGF-BB / PDGFR-beta signal modulates the excitatory synaptic transmission during hypoxia.
引用
收藏
页码：477 / 481
页数：5
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