Stereoselective synthesis of 2,4,6-trisubstituted tetrahydropyrans by the use of cyclopropanols as homoenols

被引：29

作者：

Lee, Hyung Goo ^{[1
]}

Lysenko, Ivan L. ^{[1
]}

Cha, Jin Kun ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 18期

关键词：

cyclization; cyclopropanols; homoenols; synthetic methods; tetrahydropyrans;

D O I：

10.1002/anie.200700172

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A convenient method for preparing all-cis 2,4,6-trisubstituted tetrahydropyrans and the corresponding 2,6-trans isomers has been developed. This trimethylsityl triflate mediated coupling of cyclopropanols with a 2-hydroxyalkyl side chain to aldehydes (see scheme) is also suitable for the coupling of two large subunits to generate structural complexity in a rapid and highly convergent manner. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3326 / 3328

页数：3

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