Massive infiltration of bone marrow in colon carcinoma after treatment with activated protein C

被引:9
|
作者
Pleyer, Lisa
Went, Philip
Russ, Gudrun
Prinz, Erika
Faber, Viktoria
Roewert, Hans-Joachim
Karlbauer, Renate
Greil, Richard
机构
[1] Private Med Paracelsus Univ Salzburg, Med Dept Hematol Med Oncol Hemostaseol Rheumatol, A-5020 Salzburg, Austria
[2] Private Med Paracelsus Univ Salzburg, Dept Pathol, A-5020 Salzburg, Austria
[3] Private Med Paracelsus Univ Salzburg, Dept Anesthesiol, A-5020 Salzburg, Austria
[4] Univ Basel Hosp, Dept Pathol, CH-4031 Basel, Switzerland
关键词
activated protein C; bone marrow infiltration; colorectal cancer; sepsis;
D O I
10.1007/s00508-007-0774-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We present an unusual case of localized colorectal carcinoma complicated by sepsis which was treated with activated protein C (APC). Shortly after treatment the patient developed symptomatic metastases to the bone marrow (BM). Destruction of bones by colorectal cancer (CRC) is rare, although BM micrometastases are frequently observed. However, overt symptomatic BM metastasis is an exotic rarity. APC interacts with molecules and modulates pathways that are unquestionably involved in tumorigenesis and formation of metastases. Therefore a possible contributory role of the anti-inflammatory and immunomodulatory therapy in the rapid evolution of the disease cannot be excluded. Questions concerning the relevance and contribution of sepsis, treatment with APC, exquisitely high levels of non-thrombosis-associated D-dimer and CA19-9 to this highly uncommon course of disease are discussed. The lesson learned from this case is that APC may have contributed to the massive invasion of BM by colonic cancer cells in our patient and that APC should therefore be used with extreme restraint in patients with potentially curable cancer.
引用
收藏
页码:254 / 258
页数:5
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