First total synthesis of the marine alkaloids purpurone and ningalin C

被引：42
|
作者：
Peschko, C [1 ]
Steglich, W [1 ]
机构：
[1] Univ Munich, Dept Chem, D-81377 Munich, Germany
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 49期
关键词：
purpurone; ningalins; marine natural products; ACL inhibitors; pyrrole alkaloids;
D O I：
10.1016/S0040-4039(00)01614-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Purpurone is obtained from 3-(3,4-dimethoxyphenyl)pyruvic acid, 2-(4-methoxyphenyl)ethylamine and 2',2',2'-trichloroethyl 2-bromo-2-(3,4-dimethoxyphenyl)acetate in seven steps with an overall yield of 11%. Ningalin C is synthesized from 1-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-bis-(3,4-dimethoxyphenyl)-1H-pyrrole and methyl 2-diazo-2-(3,4-dimethoxyphenyl)acetate in five steps with a total yield of 19%. (C) 2000 Published by Elsevier Science Ltd.
引用
收藏
页码：9477 / 9481
页数：5
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