Androgen Receptor-Mediated Transcription in Prostate Cancer

被引:16
|
作者
Ozturan, Dogancan [1 ,2 ]
Morova, Tunc [3 ]
Lack, Nathan A. [1 ,2 ,3 ]
机构
[1] Koc Univ, Sch Med, TR-34450 Istanbul, Turkey
[2] Koc Univ, Koc Univ Res Ctr Translat Med KUTTAM, TR-34450 Istanbul, Turkey
[3] Univ British Columbia, Vancouver Prostate Ctr, Dept Urol Sci, Vancouver, BC V6H 3Z6, Canada
关键词
androgen receptor; enhancers; prostate cancer; gene transcription; 3D genome organization; AR cistrome; RESPONSE ELEMENT; FACTOR-BINDING; DNA ELEMENTS; DEPENDENT TRANSCRIPTION; MAMMALIAN GENOMES; ENHANCER ACTIVITY; GENE-REGULATION; ANTIGEN GENE; CHROMATIN; COACTIVATOR;
D O I
10.3390/cells11050898
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Androgen receptor (AR)-mediated transcription is critical in almost all stages of prostate cancer (PCa) growth and differentiation. This process involves a complex interplay of coregulatory proteins, chromatin remodeling complexes, and other transcription factors that work with AR at cis-regulatory enhancer regions to induce the spatiotemporal transcription of target genes. This enhancer-driven mechanism is remarkably dynamic and undergoes significant alterations during PCa progression. In this review, we discuss the AR mechanism of action in PCa with a focus on how cis-regulatory elements modulate gene expression. We explore emerging evidence of genetic variants that can impact AR regulatory regions and alter gene transcription in PCa. Finally, we highlight several outstanding questions and discuss potential mechanisms of this critical transcription factor.
引用
收藏
页数:19
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