Chemical constituents of Vietnamese mangrove Hibiscus tiliaceus with antioxidant and alpha-glucosidase inhibitory activity

被引：9

作者：

Le Ba Vinh ^{[1
,2
]}

Nguyen Thi Minh Nguyet ^{[1
]}

Chu Duc Thanh ^{[1
]}

Tran Thu Huong ^{[3
]}

Le Huyen Tram ^{[3
]}

Nguyen Van Thon ^{[3
]}

Nguyen Hoang Min ^{[3
]}

Nguyen Phuong Thao ^{[2
]}

Hwang, Inkyu ^{[1
]}

Yang, Seo Young ^{[1
]}

Kim, Young Ho ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Daejeon, South Korea

[2] VAST, Inst Marine Biochem IMBC, Hanoi, Vietnam

[3] HUST, SCE, Hanoi, Vietnam

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 17期

基金：

新加坡国家研究基金会;

关键词：

Hibiscus tiliaceus; Malvaceae; megastigmane; antioxidant; alpha-glucosidase; FLAVONOIDS; TRITERPENOIDS; GLYCOSIDES;

D O I：

10.1080/14786419.2019.1672065

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Using various chromatographic techniques, a total of 15 compounds, including one novel megastigmane named tiliaceic acid A (1) and 14 known compounds, were isolated from the traditional medicinal Vietnamese mangrove Hibiscus tiliaceus. Their structures were confirmed based on spectroscopic experiments including, UV, 1 D- and 2 D-NMR, HR-ESI-MS, and ECD analysis. The antioxidant and alpha-glucosidase inhibitory activities of the isolated compounds from H. tiliaceus were evaluated for the first time. Compound 2 showed strong alpha-glucosidase inhibitory activity with an IC50 of 77.78 +/- 1.00 mu M compared with the positive control acarbose at 105.71 +/- 2.29 mu M.

引用

页码：2899 / 2904

页数：6

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