共 39 条
- [31] SAFETY, TOLERABILITY AND ANTIVIRAL ACTIVITY OF MK-7009, A NOVEL INHIBITOR OF THE HEPATITIS C VIRUS NS3/4A PROTEASE, IN PATIENTS WITH CHRONIC HCV GENOTYPE 1 INFECTIONHEPATOLOGY, 2008, 48 (04) : 403A - 404ALawitz, Eric J.Sulkowski, Mark S.Jacobson, Ira M.Faruqui, ShabanKraft, Walter K.Maliakkal, BenedictAl-Ibrahim, MohamedGhalib, Reem H.Gordon, Stuart C.Kwo, PaulRockstroh, JuergenMiller, MichelleHwang, PeggyGress, JacquelineQuirk, Erin
- [32] Phase 1 study assessing the safety, pharmacokinetics, and antiviral activity of CC-31244, a pan-genotypic, potent non-nucleoside NS5B polymerase inhibitor for the treatment of hepatitis C virus infectionJOURNAL OF HEPATOLOGY, 2017, 66 (01) : S720 - S720Lee, S.Pascual, L.Pattassery, J.Sulkowski, M.
- [33] From benzimidazole to indole-5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase. Part 1: Indole C-2 SAR and discovery of diamide derivatives with nanomolar potency in cell-based subgenomic repliconsBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (12) : 3658 - 3663Beaulieu, Pierre L.Gillard, JamesJolicoeur, EricDuan, JianminGarneau, MichelKukolj, GeorgePoupart, Marc-Andre
- [34] EVALUATION OF PHARMACOKINETIC DRUG-DRUG INTERACTION (DDI) BETWEEN BMS-791325, AN NS5B NON-NUCLEOTIDE POLYMERASE INHIBITOR, DACLATASVIR AND ASUNAPREVIR IN TRIPLE COMBINATION IN HCV GENOTYPE 1-INFECTED PATIENTSJOURNAL OF HEPATOLOGY, 2013, 58 : S184 - S184Wang, X.Li, W.Huang, S. -P.He, B.Chung, E.Griffies, A.Cooney, E.Hughes, E.Kandoussi, H.Sims, K.Gardiner, D.Bertz, R.Eley, T.
- [35] A PHASE 2A STUDY OF BMS-791325, AN NS5B POLYMERASE INHIBITOR, WITH PEGINTERFERON ALFA-2A AND RIBAVIRIN IN TREATMENT-NAIVE PATIENTS WITH GENOTYPE 1 CHRONIC HEPATITIS C INFECTIONJOURNAL OF HEPATOLOGY, 2012, 56 : S460 - S460Tatum, H.Thuluvath, P.Lawitz, E.Martorell, C. T.Demicco, M.Cohen, S.Rustgi, V.Ravendhran, N.Ghalib, R.Hanson, J.Zamparo, J.Yang, R.Hughes, E.Cooney, E.
- [36] SOUND-C2: SVR4, 12, and 24 concordance in genotype (GT) 1 HCV patients receiving interferon (IFN)-free treatment with the HCV NS3/4A protease inhibitor BI 201335 and the NS5B polymerase inhibitor BI 207127HEPATOLOGY, 2012, 56 : 569A - 569AZeuzem, StefanSoriano, VincentAsselah, TarikBronowicki, Jean-PierreLohse, Ansgar W.Mullhaupt, BeatSchuchmann, MarcusBourliere, MarcButi, MariaRoberts, Stuart K.Gone, Edward J.Stern, Jerry O.Vinisko, RichardHerichova, IvonaBoecher, Wulf O.Mensa, Federico J.
- [37] Discovery of N-[4-[6-tert-Butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C Virus NS5B PolymeraseJOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (05) : 1914 - 1931Talamas, Francisco X.Abbot, Sarah C.Anand, ShaliniBrameld, Ken A.Carter, David S.Chen, JunDavis, Danade Vicente, JavierFung, Amy D.Gong, LeyiHarris, Seth F.Inbar, PetraLabadie, Sharada S.Lee, Eun K.Lemoine, RemyLe Pogam, SophieLeveque, VincentLi, JimMcIntosh, JoelNajera, IsabelPark, JaehyeonRailkar, ArunaRajyaguru, SonalSangi, MichaelSchoenfeld, Ryan C.Staben, Leanna R.Tan, YunchouTaygerly, Joshua P.Villasenor, Armando G.Weller, Paul E.
- [38] Discovery of (7R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus NS5B PolymeraseJOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (01) : 289 - 301Narjes, FrankCrescenzi, BenedettaFerrara, MarcoHabermann, JorgColarusso, StefaniaFerreira, Maria del Rosario RicoStansfield, IanMackay, Angela ClaireConte, ImmacolataErcolani, CaterinaZaramella, SimonePalumbi, Maria-CeciliaMeuleman, PhilipLeroux-Roels, GeertGiuliano, ClaudioFiore, FabrizioDi Marco, StefaniaBaiocco, PaolaKoch, UweMigliaccio, GiovanniAltamura, SergioLaufer, RalphDe Francesco, RaffaeleRowley, Michael
- [39] Discovery of 5-(3-((1, 3-difluoro-2-(fluoromethyl)propan-2-yl)carbamoyl)phenyl)-6-(N-(2-fluoroethyl)methylsulfonamido)-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide, the first orally bioavailable pan-genotype coverage HCV NS5B inhibitor with sulfonamide moiety at C-6 of benzofuran coreABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 250Yin, ZhiweiZhang, ZhongxingWang, TaoParcella, KyleEastman, KyleGrant-Young, KatharineYeung, Kap-SunWang, Ying-KaiFang, HuaLemm, JulieZhuo, XiaoliangLiu, MengpingMosure, KathyKrause, RudolphRoberts, SusanSoars, MattKadow, John