Imposing specificity by localization: Mechanism and evolvability

被引：0
|
作者：
Ptashne, M [1 ]
Gann, A [1 ]
机构：
[1] Sloan Kettering Canc Inst, Mol Biol Program, New York, NY 10021 USA
来源：
EVOLUTION AS COMPUTATION | 2002年
关键词：
D O I：
暂无
中图分类号：
TP301 [理论、方法];
学科分类号：
081202 ;
摘要：
Cells detect extracellular signals by allostery and then give those signals meaning by "regulated localization". We suggest that this formulation applies to many biological processes and is particularly well illustrated by the mechanisms of gene regulation. Analysis of these mechanisms reveals that regulated localization requires simple molecular interactions that are readily used combinatorially. This system of regulation is highly "evolvable", and its use accounts, at least in part, for the nature of the complexities observed in biological systems.
引用
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页码：179 / 200
页数：22
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