An autopsy case of COVID-19-like acute respiratory distress syndrome after mRNA-1273 SARS-CoV-2 vaccination

被引：5

作者：

Yoshimura, Yukihiro ^{[1
]}

Sasaki, Hiroaki ^{[1
]}

Miyata, Nobuyuki ^{[1
]}

Miyazaki, Kazuhito ^{[2
]}

Okudela, Koji ^{[3
]}

Tateishi, Yoko ^{[4
]}

Hayashi, Hiroyuki ^{[4
]}

Kawana-Tachikawa, Ai ^{[5
]}

Iwashita, Hiromichi ^{[3
]}

Maeda, Kazuho ^{[6
]}

Ihama, Yoko ^{[6
]}

Hatayama, Yasuyoshi ^{[7
]}

Ryo, Akihide ^{[7
]}

Tachikawa, Natsuo ^{[1
]}

机构：

[1] Yokohama Municipal Citizens Hosp, Dept Infect Dis, Yokohama, Kanagawa, Japan

[2] Yokohama Municipal Citizens Hosp, Dept Resp Med, Yokohama, Kanagawa, Japan

[3] Yokohama City Univ, Dept Pathol, Grad Sch Med, Yokohama, Kanagawa, Japan

[4] Yokohama Municipal Citizens Hosp, Dept Pathol, Yokohama, Kanagawa, Japan

[5] Natl Inst Infect Dis, AIDS Res Ctr, Tokyo, Japan

[6] Yokohama City Univ, Dept Legal Med, Grad Sch Med, Yokohama, Kanagawa, Japan

[7] Yokohama City Univ, Dept Microbiol, Sch Med, Yokohama, Kanagawa, Japan

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2022年 / 121卷

关键词：

COVID-19; vaccine; acute respiratory distress syndrome; autopsy;

D O I：

10.1016/j.ijid.2022.04.057

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We report the first case with COVID-19-like acute respiratory distress syndrome after mRNA-1273 SARS-CoV-2 vaccination. An 88-year-old woman developed dyspnea several hours after vaccination with the second dose of mRNA-1273. She was hospitalized on day nine due to worsening dyspnea. Chest computed tomography showed bilateral ground-glass opacities and consolidations, mainly in the peripheral lung areas. Repeat polymerase chain reaction tests for SARS-CoV-2 were negative, although the serum level of antibodies against spike protein was extremely elevated. Her condition did not improve with high-dose corticosteroids and high-flow nasal cannula oxygen therapy; she died on day 18. Autopsy findings revealed very early-phase diffuse alveolar damage in the whole lung without other lung diseases. The clinical and pathological findings suggested vaccine-induced acute respiratory distress syndrome. Serological and pathological tests might be useful to differentiate the disease from COVID-19. (C) 2022 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

引用

页码：98 / 101

页数：4

共 50 条

[41] SARS-CoV-2 causes COVID-19-like disease in cynomolgus macaques
Alexandra Le Bras
Lab Animal, 2020, 49 : 174 - 174
[42] Development of pemphigus vulgaris after the second dose of the mRNA-1273 SARS-Cov-2 vaccine
Koutlas, Ioannis G.
Camara, Renee
Argyris, Prokopios P.
Davis, Mark Denis P.
Miller, Daniel D.
ORAL DISEASES, 2022, 28 : 2612 - 2613
[43] Bell's Palsy After 24 Hours of mRNA-1273 SARS-CoV-2 Vaccine
Iftikhar, Haris
Noor, Syeda Mishkaat U.
Masood, Maarij
Bashir, Khalid
CUREUS JOURNAL OF MEDICAL SCIENCE, 2021, 13 (06)
[44] Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults
Anderson, E. J.
Rouphael, N. G.
Widge, A. T.
Jackson, L. A.
Roberts, P. C.
Makhene, M.
Chappell, J. D.
Denison, M. R.
Stevens, L. J.
Pruijssers, A. J.
McDermott, A. B.
Flach, B.
Lin, B. C.
Doria-Rose, N. A.
O'Dell, S.
Schmidt, S. D.
Corbett, K. S.
Swanson, P. A., II
Padilla, M.
Neuzil, K. M.
Bennett, H.
Leav, B.
Makowski, M.
Albert, J.
Cross, K.
Edara, V. V.
Floyd, K.
Suthar, M. S.
Martinez, D. R.
Baric, R.
Buchanan, W.
Luke, C. J.
Phadke, V. K.
Rostad, C. A.
Ledgerwood, J. E.
Graham, B. S.
Beigel, J. H.
NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (25): : 2427 - 2438
[45] SARS-CoV-2 causes COVID-19-like disease in cynomolgus macaques
Le Bras, Alexandra
LAB ANIMAL, 2020, 49 (06) : 174 - 174
[46] Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase
El Sahly, H. M.
Baden, L. R.
Essink, B.
Doblecki-Lewis, S.
Martin, J. M.
Anderson, E. J.
Campbell, T. B.
Clark, J.
Jackson, L. A.
Fichtenbaum, C. J.
Zervos, M.
Rankin, B.
Eder, F.
Feldman, G.
Kennelly, C.
Han-Conrad, L.
Levin, M.
Neuzil, K. M.
Corey, L.
Gilbert, P.
Janes, H.
Follmann, D.
Marovich, M.
Polakowski, L.
Mascola, J. R.
Ledgerwood, J. E.
Graham, B. S.
August, A.
Clouting, H.
Deng, W.
Han, S.
Leav, B.
Manzo, D.
Pajon, R.
Schodel, F.
Tomassini, J. E.
Zhou, H.
Miller, J.
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (19): : 1774 - 1785
[47] Tracking B cell responses to the SARS-CoV-2 mRNA-1273 vaccine
de Assis, Felipe Lopes
Hoehn, Kenneth B.
Zhang, Xiaozhen
Kardava, Lela
Smith, Connor D.
El Merhebi, Omar
Buckner, Clarisa M.
Trihemasava, Krittin
Wang, Wei
Seamon, Catherine A.
Chen, Vicky
Schaughency, Paul
Cheung, Foo
Martins, Andrew J.
Chiang, Chi-, I
Li, Yuxing
Tsang, John S.
Chun, Tae-Wook
Kleinstein, Steven H.
Moir, Susan
CELL REPORTS, 2023, 42 (07):
[48] Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults
Evan J Anderson
四川生理科学杂志, 2020, 42 (04) : 468 - 468
[49] Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants
Choi, Angela
Koch, Matthew
Wu, Kai
Dixon, Groves
Oestreicher, Judy
Legault, Holly
Stewart-Jones, Guillaume B. E.
Colpitts, Tonya
Pajon, Rolando
Bennett, Hamilton
Carfi, Andrea
Edwards, Darin K.
JOURNAL OF VIROLOGY, 2021, 95 (23)
[50] Pityriasis Rosea Shortly After mRNA-1273 COVID-19 Vaccination
Shin, Sun Hye
Hong, Jun Ki
Hong, Soon Auck
Li, Kapsok
Yoo, Kwang Ho
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2022, 114 : 88 - 89

← 1 2 3 4 5 →