A single-cell transcriptome atlas of the aging human and macaque retina

被引：0

作者：

Yi, Wenyang ^{[1
]}

Lu, Yufeng ^{[2
,6
]}

Zhong, Suijuan ^{[3
,8
]}

Zhang, Mei ^{[1
,4
]}

Sun, Le ^{[2
,6
]}

Dong, Hao ^{[2
,6
]}

Wang, Mengdi ^{[2
]}

Wei, Min ^{[1
]}

Xie, Haohuan ^{[1
]}

Qu, Hongqiang ^{[9
]}

Peng, Rongmei ^{[9
]}

Hong, Jing ^{[9
]}

Yao, Ziqin ^{[1
]}

Tong, Yunyun ^{[1
]}

Wang, Wei ^{[2
,6
]}

Ma, Qiang ^{[2
,6
]}

Liu, Zeyuan ^{[2
,6
]}

Ma, Yuqian ^{[1
]}

Li, Shouzhen ^{[1
]}

Yin, Chonghai ^{[2
]}

Liu, Jianwei ^{[2
]}

Ma, Chao ^{[10
]}

Wang, Xiaoqun ^{[2
,5
,6
,7
,11
,12
]}

Wu, Qian ^{[3
,8
]}

Xue, Tian ^{[1
,4
,5
,11
]}

机构：

[1] Univ Sci & Technol China, Affiliated Hosp USTC 1, Eye Ctr,Div Life Sci & Med, Sch Life Sci,Hefei Natl Lab Phys Sci & Microscale, Hefei 230026, Peoples R China

[2] Chinese Acad Sci, Inst Brain Intelligence Technol Shanghai, Bioland Lab Guangzhou, State Key Lab Brain & Cognit Sci,Inst Biophys, Beijing 100101, Peoples R China

[3] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China

[4] Univ Sci & Technol China, Neurodegenerat Disorder Res Ctr, CAS Key Lab Brain Funct & Dis, Hefei 230026, Peoples R China

[5] Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China

[6] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[7] Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing Inst Brain Disorders, Beijing 100069, Peoples R China

[8] Beijing Normal Univ, IDG Mcbovern Inst Brain Res, Beijing 100875, Peoples R China

[9] Peking Univ Third Hosp, Dept Ophthalmol, Beijing Key Lab Restorat Damaged Ucular Nerve, Beijing 100191, Peoples R China

[10] Chinese Acad Med Sci & Peking Union Med Coll, Beijing 100730, Peoples R China

[11] Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai 200031, Peoples R China

[12] Chinese Acad Sci, Natl Resource Ctr Nonhuman Primates Kunming, Primate Res Ctr IBP Beijing, Beijing 100101, Peoples R China

来源：

NATIONAL SCIENCE REVIEW | 2021年 / 8卷 / 04期

基金：

中国国家自然科学基金;

关键词：

single-cell RNA sequencing; primate retina; aging; cell heterogeneity; age-related disease; cell-cell communication; PROGENITOR CELLS; EXPRESSION; METALLOTHIONEIN; DEGENERATION; MECHANISMS; MUTATION; TARGET; FETAL; ROD;

D O I：

10.1093/nsr/nwaa179

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human retina is a complex neural tissue that detects light and sends visual information to the brain. However, the molecular and cellular processes that underlie aging primate retina remain unclear. Here, we provide a comprehensive transcriptomic atlas based on 119 520 single cells of the foveal and peripheral retina of humans and macaques covering different ages. The molecular features of retinal cells differed between the two species, suggesting distinct regional and species specializations of the human and macaque retinae. In addition, human retinal aging occurred in a region- and cell-type-specific manner. Aging of human retina exhibited a foveal to peripheral gradient. MYO9A(-) rods and a horizontal cell subtype were greatly reduced in aging retina, indicating their vulnerability to aging. Moreover, we generated a dataset showing the cell-type- and region-specific gene expression associated with 55 types of human retinal disease, which provides a foundation to understanding of the molecular and cellular mechanisms underlying human retinal diseases. Such datasets are valuable to understanding of the molecular characteristics of primate retina, as well as molecular regulation of aging progression and related diseases.

引用

页数：18

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