1,5-Iodonaphthyl azide-inactivated V3526 protects against aerosol challenge with virulent venezuelan equine encephalitis virus

被引：5
|
作者：
Gupta, Paridhi [1 ]
Sharma, Anuj [1 ]
Spurgers, Kevin B. [2 ]
Bakken, Russell R. [2 ]
Eccleston, Lori T. [2 ]
Cohen, Jeffrey W. [2 ]
Honnold, Shelley P. [2 ]
Glass, Pamela J. [2 ]
Maheshwari, Radha K. [1 ]
机构：
[1] Uniformed Serv Univ Hlth Sci, Dept Pathol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA
[2] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA
来源：
VACCINE | 2016年 / 34卷 / 25期
关键词：
Venezuelan equine encephalitis; Vaccine; Inactivated; Iodonaphthyl azide; Aerosol challenge; Protection; STRUCTURAL INTEGRITY; NONHUMAN-PRIMATES; PRESERVATION; VACCINES; INFECTION; RESPONSES; ANTIBODY; VEEV;
D O I：
10.1016/j.vaccine.2016.04.049
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Venezuelan equine encephalitis virus (VEEV) is a New World alphavirus. VEEV is highly infectious in aerosolized form and has been identified as a bio-terrorism agent. There is no licensed vaccine for prophylaxis against VEEV. The current IND vaccine is poorly immunogenic and does not protect against an aerosol challenge with virulent VEEV. We have previously shown that VEEV inactivated by 1,5-iodonaphthyl azide (INA) protects against footpad challenge with virulent VEEV. In this study, we inactivated an attenuated strain of VEEV, V3526, with INA and evaluated its protective efficacy against aerosol challenge with wild type VEEV. We demonstrated that among three routes of immunization, intramuscular immunization with INA-inactivate V3526 (INA-iV3526) provided complete protection against aerosol challenge with virulent VEEV. Our data suggests that INA-iV3526 can be explored further for development as an effective vaccine candidate against aerosol challenge of virulent VEEV. (C) 2016 Published by Elsevier Ltd.
引用
收藏
页码：2762 / 2765
页数：4
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