The Philadelphia chromosome as a secondary change in leukemia: Three case reports and an overview of the literature

被引：14
|
作者：
Chen, Z
Morgan, R
Notohamiprodjo, M
Meloni-Ehrig, A
Schuster, RT
Bennett, JS
Cohen, JD
Stone, JF
Sandberg, AA
机构：
[1] Genzyme Genet, Scottsdale, AZ USA
[2] Paoli Mem Hosp, Paoli, PA USA
[3] Pediat Hematol Oncol Associates, Phoenix, AZ USA
来源：
CANCER GENETICS AND CYTOGENETICS | 1998年 / 101卷 / 02期
关键词：
D O I：
10.1016/S0165-4608(97)00262-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Three cases of acute nonlymphocytic leukemia with a Philadelphia chromosome (Ph) as a secondary abnormality are reported. The Ph was late-appearing in one patient and appeared as an additional anomaly in the other two patients. Fluorescence in situ hybridization studies of the first patient identified the presence of a minor BCR/ABL rearrangement. The findings of these cases support the conclusion that the Ph plays a role not only in leukemogenesis, but also in disease progression. An overview of the literature dealing with similar cases is also presented. (C) Elsevier Science Inc., 1998.
引用
收藏
页码：148 / 151
页数：4
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