Three patients with multiple myeloma developing secondary lymphoblastic leukemia: case reports and review of the literature

被引：5
|
作者：
Li Junxun [1 ]
Liu Junru [3 ]
Chen Meilan [3 ]
Liang Chujia [1 ]
Chen Shaoqian [1 ]
Zhan Jieyu [2 ]
Ye Zhuangjian [1 ]
Zhang Fan [1 ]
Ouyang Juan [1 ]
Cheng Jing [1 ]
Li Juan [3 ]
机构：
[1] Sun Yatsen Univ, Dept Lab Sci, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China
[2] First Hosp Baiyun Dist, Dept Pediat, Guangzhou, Guangdong, Peoples R China
[3] Sun Yatsen Univ, Dept Hematol, Affiliated Hosp 1, 58 Zhongshan Er Rd, Guangzhou 510080, Guangdong, Peoples R China
来源：
TUMORI | 2016年 / 102卷
关键词：
Lymphoblastic leukemia; Multiple myeloma; Secondary malignancy; MYELODYSPLASTIC SYNDROME; 2ND MALIGNANCIES; THALIDOMIDE; THERAPY; LENALIDOMIDE; LYMPHOCYTES; MAINTENANCE; PREDNISONE; MELPHALAN; CANCER;
D O I：
10.5301/tj.5000377
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Introduction: Secondary lymphoblastic leukemia has been rarely reported in patients with multiple myeloma. Case reports: We report 3 cases of secondary lymphoblastic leukemia in multiple myeloma patients. They shared a similar phenotype of myeloma cells and secondary lymphoblasts. The chemotherapy treatments in the 3 patients were complex due to various factors. Conclusions: Multiple immune defects caused by exposure to a variety of agents can play an important role in the development of secondary lymphoblastic leukemia. Microscopic morphology and flow cytometry are important means to detect secondary malignancies in multiple myeloma. Further clinical, experimental and genetic studies of secondary malignancies in multiple myeloma will be necessary in the future.
引用
收藏
页码：S131 / S136
页数：6
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