Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice

被引：0
|
作者：
Huang, TT [1 ]
Carlson, EJ [1 ]
Gillespie, AM [1 ]
Shi, YP [1 ]
Epstein, CJ [1 ]
机构：
[1] Univ Calif San Francisco, Dept Pediat, Div Med Genet, San Francisco, CA 94143 USA
来源：
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2000年 / 55卷 / 01期
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D O I：
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中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Oxidative damage has been implicated in the aging process and in a number of degenerative diseases. To investigate the role of oxygen radicals in the aging profess in mammals, the life spans of transgenic mice on a CD-1 background expressing increased levels of CuZn superoxide dismutase (CuZnSOD), the enzyme that metabolizes superoxide radicals, were determined. Homozygous transgenic mice with a two- to five-fold elevation of CuZnSOD in various tissues showed a slight reduction of life span, whereas hemizygous mice with a 1.5- to 3-fold increase of CuZnSOD showed no difference in life span from that of the nontransgenic littermate controls. The results suggest that constitutive and ubiquitous overexpression of CuZnSOD alone is not sufficient to extend the life spans of transgenic mice.
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页码：B5 / B9
页数：5
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