The B cell-specific coactivator OBF-1 (OCA-B, Bob-1) is inducible in T cells and its expression is dispensable for IL-2 gene induction

被引：27

作者：

Sauter, P ^{[1
]}

Matthias, P ^{[1
]}

机构：

[1] Friedrich Miescher Inst, CH-4058 Basel, Switzerland

来源：

IMMUNOBIOLOGY | 1997年 / 198卷 / 1-3期

关键词：

D O I：

10.1016/S0171-2985(97)80041-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The transcriptional coactivator variously known as OBF-1, OCA-B or Bob-1 has previously been shown to be expressed in a highly B cell-specific manner. Here we show that expression of the OBF-1 gene is also observed in several T cell lines as well as in primary T cells following activation. This suggests that this coactivator may also be involved in transcriptional control in T lymphocytes. In addition we show that several potential T cell-specific target genes which have octamer sites in their regulatory regions, such as the genes coding for interleukin-2, -3 and -4, are still properly regulated in T cells isolated from OBF-1(-/-) mice.

引用

页码：207 / 216

页数：10

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