Investigation of chromosome 17q as a locus for human essential hypertension in African Caribbeans

被引：5
|
作者：
Knight, J [1 ]
Gardner, GTB [1 ]
Clark, AJL [1 ]
Caulfield, MJ [1 ]
机构：
[1] St Bartholomews & Royal London Sch Med & Dent, London, England
来源：
JOURNAL OF HUMAN HYPERTENSION | 2000年 / 14卷 / 06期
关键词：
essential hypertension; linkage; chromosome; 17; comparative mapping; African Caribbean;
D O I：
10.1038/sj.jhh.1001025
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Essential hypertension is a major risk factor for cardiovascular disease in humans, and originates from both genetic and environmental factors. Data from animal and more recently human studies have indicated the presence of a gene influencing blood pressure on human chromosome 17. This study tested for linkage of markers located on chromosome 17q to essential hypertension in African Caribbean hypertensive families, No support of linkage was found between the markers studied and hypertension, however only genes of a lamda sib value of less than 1.8 could be excluded.
引用
收藏
页码：385 / 387
页数：3
相关论文
共 50 条
  • [41] Linkage found to chromosome 17q in Scandinavian sib pairs with multiple sclerosis
    Oturai, A
    Larsen, F
    Ryder, LP
    Madsen, HO
    Hillert, J
    Frederikson, S
    Sandberg-Wollheim, M
    Laaksonen, M
    Harboe, H
    Sawcer, S
    Fugger, L
    Soerensen, PS
    Svejgaard, A
    NEUROLOGY, 2000, 54 (07) : A349 - A349
  • [42] Prohibitin mutations are uncommon in prostate cancer families linked to chromosome 17q
    White, K. A.
    Lange, E. M.
    Ray, A. M.
    Wojno, K. J.
    Cooney, K. A.
    PROSTATE CANCER AND PROSTATIC DISEASES, 2006, 9 (03) : 298 - 302
  • [43] Gain of distal chromosome arm 17q is not associated with poor prognosis in neuroblastoma
    Spitz, R
    Hero, B
    Ernestus, K
    Berthold, F
    CLINICAL CANCER RESEARCH, 2003, 9 (13) : 4835 - 4840
  • [44] PATTERNS OF ALLELIC LOSS ON CHROMOSOME 17Q IN SPORADIC CARCINOMAS OF OVARY AND BREAST
    FRANK, TS
    CADUFF, RF
    SVOBODA, SM
    AMERICAN JOURNAL OF HUMAN GENETICS, 1995, 57 (04) : 335 - 335
  • [45] Gain of chromosome arm 17q predicts unfavourable outcome in neuroblastoma patients
    Lastowska, M
    Cotterill, S
    Pearson, ADJ
    Roberts, P
    McGuckin, A
    Lewis, I
    Bown, N
    EUROPEAN JOURNAL OF CANCER, 1997, 33 (10) : 1627 - 1633
  • [46] Gain of 17q chromosome in a pediatric AML case with 9;11 translocation
    Russo, I
    Morerio, C
    Rapella, A
    Rosanda, C
    Lesz, A
    Basso, G
    Pasquali, F
    Panarello, C
    CYTOGENETICS AND CELL GENETICS, 1999, 85 (1-2): : 85 - 85
  • [47] Further evidence supporting linkage of hereditary neuralgic amyotrophy to chromosome 17q
    Wehnert, M
    Timmerman, V
    Spoelders, P
    Meuleman, J
    Nelis, E
    Van Broeckhoven, C
    NEUROLOGY, 1997, 48 (06) : 1719 - 1721
  • [48] DETECTION OF AN I(17Q) CHROMOSOME BY FLUORESCENT INSITU HYBRIDIZATION WITH A CHROMOSOME 17 ALPHA-SATELLITE DNA PROBE
    NAKAGAWA, H
    INAZAWA, J
    MISAWA, S
    TANAKA, S
    TAKASHIMA, T
    TANIWAKI, M
    ABE, T
    KASHIMA, K
    CANCER GENETICS AND CYTOGENETICS, 1992, 62 (02) : 140 - 143
  • [49] Chromosome 17 and the inducible nitric oxide synthase gene in human essential hypertension
    Sue Rutherford
    Matthew P. Johnson
    Robert P. Curtain
    Lyn R. Griffiths
    Human Genetics, 2001, 109 : 408 - 415
  • [50] Chromosome 17 and the inducible nitric oxide synthase gene in human essential hypertension
    Rutherford, S
    Johnson, MP
    Curtain, RP
    Griffiths, LR
    HUMAN GENETICS, 2001, 109 (04) : 408 - 415
12345