Paraoxonase 1 (PON1) polymorphisms and risk for essential tremor

被引：9
|
作者：
Garcia-Martin, E. [1 ]
Martinez, C. [2 ]
Alonso-Navarro, H. [3 ,4 ]
Benito-Leon, J. [5 ,6 ]
Puertas, I. [3 ]
Rubio, L. [3 ]
Lopez-Alburquerque, T. [7 ]
Agundez, J. A. G. [1 ]
Jimenez-Jimenez, F. J. [3 ,8 ]
机构：
[1] Univ Extremadura, Sch Biol Sci, Badajoz, Spain
[2] Univ Extremadura, Sch Med, Badajoz, Spain
[3] Univ Alcala, Hosp Principe de Asturias, Madrid, Spain
[4] Hosp La Mancha Ctr, Ciudad Real, Spain
[5] Hosp Mostoles, Madrid, Spain
[6] CIBERNED, Madrid, Spain
[7] Hosp Univ Salamanca, Salamanca, Spain
[8] Hosp Sureste, Madrid, Spain
来源：
EUROPEAN JOURNAL OF NEUROLOGY | 2010年 / 17卷 / 06期
关键词：
essential tremor; genetics; paraoxonase; 1; polymorphism; risk factors; NAT2; GENE;
D O I：
10.1111/j.1468-1331.2009.02914.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: The polymorphic enzyme human serum paraoxonase 1 (PON1), encoded by the gene PON1 (chromosome 7q21.3), plays a major role in the metabolism of organophosphorus compounds. We investigated the possible association between the PON1 genotype and allelic variants of the polymorphisms Leu55Met and Glu192Arg, and the risk for essential tremor (ET). Methods: We studied the frequency of the PON1 genotypes and allelic variants in 201 patients with ET and 220 healthy controls using a PCR-RLFP method. Results: The frequencies of the PON1 genotypes and allelic variants of the polymorphisms Leu55Met and Gln192Arg did not differ significantly between patients with ET and controls. These polymorphisms were unrelated with the age of onset of ET. Conclusions: PON1 polymorphisms are not related with the risk for ET.
引用
收藏
页码：879 / 881
页数：3
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