Paraoxonase 1 (PON1) polymorphisms and risk for essential tremor

被引：9
|
作者：
Garcia-Martin, E. [1 ]
Martinez, C. [2 ]
Alonso-Navarro, H. [3 ,4 ]
Benito-Leon, J. [5 ,6 ]
Puertas, I. [3 ]
Rubio, L. [3 ]
Lopez-Alburquerque, T. [7 ]
Agundez, J. A. G. [1 ]
Jimenez-Jimenez, F. J. [3 ,8 ]
机构：
[1] Univ Extremadura, Sch Biol Sci, Badajoz, Spain
[2] Univ Extremadura, Sch Med, Badajoz, Spain
[3] Univ Alcala, Hosp Principe de Asturias, Madrid, Spain
[4] Hosp La Mancha Ctr, Ciudad Real, Spain
[5] Hosp Mostoles, Madrid, Spain
[6] CIBERNED, Madrid, Spain
[7] Hosp Univ Salamanca, Salamanca, Spain
[8] Hosp Sureste, Madrid, Spain
来源：
EUROPEAN JOURNAL OF NEUROLOGY | 2010年 / 17卷 / 06期
关键词：
essential tremor; genetics; paraoxonase; 1; polymorphism; risk factors; NAT2; GENE;
D O I：
10.1111/j.1468-1331.2009.02914.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: The polymorphic enzyme human serum paraoxonase 1 (PON1), encoded by the gene PON1 (chromosome 7q21.3), plays a major role in the metabolism of organophosphorus compounds. We investigated the possible association between the PON1 genotype and allelic variants of the polymorphisms Leu55Met and Glu192Arg, and the risk for essential tremor (ET). Methods: We studied the frequency of the PON1 genotypes and allelic variants in 201 patients with ET and 220 healthy controls using a PCR-RLFP method. Results: The frequencies of the PON1 genotypes and allelic variants of the polymorphisms Leu55Met and Gln192Arg did not differ significantly between patients with ET and controls. These polymorphisms were unrelated with the age of onset of ET. Conclusions: PON1 polymorphisms are not related with the risk for ET.
引用
收藏
页码：879 / 881
页数：3
相关论文
共 50 条
  • [1] Paraoxonase 1 (PON1) polymorphisms and risk for essential tremor
    Alonso-Navarro, H.
    Garcia-Martin, E.
    Martinez, C.
    Benito-Leon, J.
    Puertas, I.
    Rubio, L.
    Lopez-Alburquerque, T.
    Agundez, J. A. G.
    Jimenez-Jimenez, F. J.
    [J]. EUROPEAN JOURNAL OF NEUROLOGY, 2009, 16 : 169 - 169
  • [2] Paraoxonase 1 (PON1) polymorphisms and risk for migraine
    Elena García-Martín
    Carmen Martínez
    Mercedes Serrador
    Hortensia Alonso-Navarro
    Francisco Navacerrada
    José A. G. Agúndez
    Félix Javier Jiménez-Jiménez
    [J]. Journal of Neurology, 2010, 257 : 1482 - 1485
  • [3] Paraoxonase 1 (PON1) polymorphisms and risk for migraine
    Garcia-Martin, Elena
    Martinez, Carmen
    Serrador, Mercedes
    Alonso-Navarro, Hortensia
    Navacerrada, Francisco
    Agundez, Jose A. G.
    Javier Jimenez-Jimenez, Felix
    [J]. JOURNAL OF NEUROLOGY, 2010, 257 (09) : 1482 - 1485
  • [4] Association of paraoxonase 1 (PON1) gene polymorphisms and concentration with essential hypertension
    Cosan, Didem Turgut
    Colak, E.
    Saydam, F.
    Yazici, H. U.
    Degirmenci, I.
    Birdane, A.
    Colak, E.
    Gunes, H. V.
    [J]. CLINICAL AND EXPERIMENTAL HYPERTENSION, 2016, 38 (07) : 602 - 607
  • [5] Functional genomics of the paraoxonase (PON1) polymorphisms
    Cole, TB
    Jarvik, GP
    Richter, RJ
    Jampsa, RL
    Carlson, CS
    Rieder, MJ
    Nickerson, DA
    Shih, DM
    Lusis, AJ
    Costa, LG
    Furlong, CE
    [J]. FASEB JOURNAL, 2003, 17 (04): : A158 - A158
  • [6] Polymorphisms in the human paraoxonase (PON1) promoter
    Brophy, VH
    Hastings, MD
    Clendenning, JB
    Richter, RJ
    Jarvik, GP
    Furlong, CE
    [J]. PHARMACOGENETICS, 2001, 11 (01): : 77 - 84
  • [7] Human paraoxonase (PON1) polymorphisms in Taiwanese
    Li, WF
    Chung, MC
    Chuang, HY
    Chang, LW
    [J]. DRUG METABOLISM REVIEWS, 2003, 35 : 66 - 66
  • [8] The effects of paraoxonase (PON1) polymorphisms in the coding region and environmental factors on serum PON1 activity
    Jintana, Sirivarasai
    Sming, Kaojarern
    Krongtong, Yoovathawom
    Thanyachai, Sura
    [J]. ANNALS OF NUTRITION AND METABOLISM, 2007, 51 : 112 - 112
  • [9] Analysis of paraoxonase-1 (PON1) gene polymorphisms in vitiligo
    Seckin, Havva Yildiz
    Kalkan, Goknur
    Benli, Ismail
    Butun, Ilknur
    Bas, Yalcin
    Takci, Zennure
    Karakus, Nevin
    [J]. TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, 2015, 40 (05): : 356 - 362
  • [10] Association of Paraoxonase 1 (PON1) polymorphisms with osteoporotic fracture risk in postmenopausal Korean women
    Kim, Beam-Jun
    Kim, Shin-Yoon
    Cho, Yoon Shin
    Kim, Bon-Jo
    Han, Bok-Ghee
    Park, Eui Kyun
    Lee, Seung Hun
    Kim, Ha Young
    Kim, Ghi Su
    Lee, Jong-Young
    Koh, Jung-Min
    [J]. EXPERIMENTAL AND MOLECULAR MEDICINE, 2011, 43 (02): : 71 - 81
12345