The Roles of MicroRNA in Pancreatic Cancer Progression

被引：6

作者：

Devi, Ramya K. T. ^{[1
]}

Karthick, Dharshene ^{[1
]}

Saravanaraj, Kirtikesav Salem ^{[1
]}

Jaganathan, M. K. ^{[1
]}

Ghorai, Suvankar ^{[2
]}

Hemdev, Sanjana Prakash ^{[3
]}

机构：

[1] SRM Inst Sci & Technol, Sch Bioengn, Fac Engn & Technol, Dept Biotechnol, Chennai, Tamil Nadu, India

[2] Raiganj Univ, Dept Microbiol, Uttar Dinajpur, India

[3] Univ Penn, Sch Engn & Appl Sci, Philadelphia, PA 19104 USA

来源：

CANCER INVESTIGATION | 2022年 / 40卷 / 08期

关键词：

Pancreatic ductal adenocarcinoma; miRNA; pancreatic cancer; downregulation; PDAC; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-SUPPRESSOR; DUCTAL ADENOCARCINOMA; SIGNALING PATHWAY; CELL-MIGRATION; PROLIFERATION; GROWTH; METASTASIS; EXPRESSION; INVASION;

D O I：

10.1080/07357907.2022.2057526

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic Ductal Adenocarcinoma (PDAC) has a poor patient survival rate in comparison with other cancer types, even after targeted therapy, chemotherapy, and immunotherapy. Therefore, a great deal needs to be done to gain a better understanding of the biology and identification of prognostic and predictive markers for the development of superior therapies. The microRNAs (miRNAs) belong to small non-coding RNAs that regulate post-transcriptional gene expression. Several shreds of evidence indicate that miRNAs play an important role in the pathogenesis of pancreatic cancer. Here we review the recent developments in miRNAs and their target role in the development, metastasis, migration, and invasion.

引用

页码：700 / 709

页数：10

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