Validation of a point-of-care rapid diagnostic test for hepatitis C for use in resource-limited settings

被引：0

作者：

Leathers, James S. ^{[1
]}

Belen Pisano, Maria ^{[2
]}

Re, Viviana ^{[2
]}

van Oord, Gertine ^{[3
]}

Sultan, Amir ^{[4
]}

Boonstra, Andre ^{[3
]}

Debes, Jose D. ^{[3
,5
]}

机构：

[1] Vanderbilt Univ, Sch Med, 2201 West End Ave, Nashville, TN 37212 USA

[2] Univ Nacl Cordoba, Inst Virol Dr JM Vanella, Fac Ciencias Med, CONICET, Ave Enfermera Gordillo S-N, Cordoba, Argentina

[3] Erasmus MC, Dept Gastroenterol & Hepatol, Wytemaweg 80, NL-3015 CE Rotterdam, Netherlands

[4] Addis Ababa Univ, Div Gastroenterol, Churchil Rd S-N, Addis Ababa, Ethiopia

[5] Univ Minnesota, Dept Med, 420 Delaware St SE, Minneapolis, MN 55455 USA

来源：

INTERNATIONAL HEALTH | 2019年 / 11卷 / 04期

关键词：

hepatitis C; rapid diagnostic test; resource-limited;

D O I：

10.1093/inthealth/ihy101

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: Treatment of HCV with direct-acting antivirals has enabled the discussion of HCV eradication worldwide. Envisioning this aim requires implementation of mass screening in resource-limited areas, usually constrained by testing costs. Methods: We validated a low-cost, rapid diagnosis test (RDT) for HCV in three different continents in 141 individuals. Results: The HCV RDT showed 100% specificity and sensitivity across different samples regardless of genotype or viral load (in samples with such information, 90%). Conclusions: The HCV test validated in this study can allow for HCV screening in areas of need when properly used.

引用

页码：314 / 315

页数：2

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