Synthesis of novel, chiral, water-soluble isothiazole derivatives

被引：3
|
作者：
Ciez, Dariusz [1 ]
Szneler, Edward
机构：
[1] Jagiellonian Univ, Dept Organ Chem, PL-30060 Krakow, Poland
[2] Jagiellonian Univ, Fac Chem, NMR Lab, PL-30060 Krakow, Poland
来源：
JOURNAL OF CHEMICAL RESEARCH-S | 2007年 / 04期
关键词：
isothiazoles; chirality; unsaturated thioamides; oxidation; water solubility;
D O I：
10.3184/030823407X203396
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This article describes an easy preparation of some optically active, water soluble N-5,2,3,4-tetrasubstituted isothiazol5(2H)-imine hydrobromides from modified L-alpha-amino acids. lsothiazole rings are created in two-step reactions by oxidation of chiral 3-amino-2,3-unsaturated thioamides.
引用
收藏
页码：200 / 202
页数：3
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